The Assay Development core facility performs design, development, validation and pilot screening of biological high-throughput assays. Our dedicated staff is skilled in various screening modalities to help design and develop de-novo
assays or convert low-throughput lab protocols (e.g. cuvette- or gel-based) into plate-based HTS assays. To date, the facility has developed more than 250 cell-based and biochemical assays. Approximately half of these assays advanced to HTS, and the other half are employed in assay panels supporting HTS hit validation and Structure-Activity Relationship (SAR) studies. The facility is an integral part of Conrad Prebys Center for Chemical Genomics
and works closely in collaboration with other cores and teams.
The HTS Assay Development core also provides direct assistance with preparing screening-related grants, guiding through assay development stages, helping design testing funnels, and generating preliminary data.