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Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
Maloney PR, Khan P, Hedrick M, Gosalia P, Milewski M, Li L, Roth GP, Sergienko E, Suyama E, Sugarman E, Nguyen K, Mehta A, Vasile S, Su Y, Stonich D, Nguyen H, Zeng FY, Novo AM, Vicchiarelli M, Diwan J, Chung TD, Smith LH, Pinkerton AB
Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60
HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.
Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F
Chem Biol. 2012 Jul 27;19(7):806-18
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.
Preuss J, Maloney P, Peddibhotla S, Hedrick MP, Hershberger P, Gosalia P, Milewski M, Li YL, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth GP, Diwan J, Chung TD, Jortzik E, Rahlfs S, Becker K, Pinkerton AB, Bode L
J Med Chem. 2012 Aug 23;55(16):7262-72
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.
Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, Heynen-Genel S, Mangravita-Novo A, Vicchiarelli M, Smith LH, Streicher JM, Caron MG, Barak LS, Bohn LM, Chung TD, Aubé J
ACS Chem Neurosci. 2012 Mar 21;3(3):221-236
High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase.
Preuss J, Hedrick M, Sergienko E, Pinkerton A, Mangravita-Novo A, Smith L, Marx C, Fischer E, Jortzik E, Rahlfs S, Becker K, Bode L
J Biomol Screen. 2012 Jul;17(6):738-51
High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.
Zhai D, Godoi P, Sergienko E, Dahl R, Chan X, Brown B, Rascon J, Hurder A, Su Y, Chung TD, Jin C, Diaz P, Reed JC
J Biomol Screen. 2012 Mar;17(3):350-60
Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.
Sergienko E, Xu J, Liu WH, Dahl R, Critton DA, Su Y, Brown BT, Chan X, Yang L, Bobkova EV, Vasile S, Yuan H, Rascon J, Colayco S, Sidique S, Cosford ND, Chung TD, Mustelin T, Page R, Lombroso PJ, Tautz L
ACS Chem Biol. 2012 Feb 17;7(2):367-77
TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors.
Madiraju C, Welsh K, Cuddy MP, Godoi PH, Pass I, Ngo T, Vasile S, Sergienko EA, Diaz P, Matsuzawa S, Reed JC
J Biomol Screen. 2012 Feb;17(2):163-76
View All Publications
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Exploiting chromatic aberration for image-based microscope autofocus.
Fuller D.N., Kellner A.L., Price J.H.
Applied Optics. 2011 August 29;50(25):4967-4976.
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Chapter 27: Cytometric features of fluorescently labeled nuclei for cell classification.
Heynen-Genel S., Price J.H.
Handbook of Medical Image Processing and Analysis, Volume 1, Second Edition by Isaac Bankman, Academic Press, (2009), pp. 453-464.
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Automated calcium measurements in live cardiomyocytes.
Charlot D., Campa V., Mercola M., Ingermanson R., McDonough P.M., Price J.H.
5th IEEE International Symposium on Biomedical Imaging (ISBI): "From Nano to Macro". May 2008, Budapest, Hungary, 4 pages, refereed meeting paper
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San Diego Center for Chemical Genomics: Opportunities and Incentives for Investigators to interact with the Burnham Institute for Medical Research and the Molecular Libraries Screening Centers Network.
Dad S.
SBS News, (2008), Front page.
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Chapter 26: The Molecular Libraries Screening Center Network: Identifying Chemical Probes of Biological Systems.
Huryn D.M., Cosford N.
(2007). Ann. Rep. Med. Chem. 42, 401-416
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San Diego Center for Chemical Genomics: A Collaborative Approach to Chemical Probe Discovery.
65. Reed J.C., Vuori K., Cosford N.
SBS News, (2006), 25, 4-5.
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