Conrad Prebys Center for Chemical Genomics

Collaborating with Pfizer to speed drug discovery

Collaborating with Pfizer to speed drug discovery

Sanford-Burnham is the latest research organization to partner with Pfizer, Inc. as part of Pfizer’s commitment to transforming research and development through a focus on translational medicine...

Florida Translational Research Program

Florida Translational Research Program

The purpose of the Florida Translational Research Program is to establish a pipeline of potential new medicines based on laboratory research discoveries in the State of Florida.

Searching for new cancer drugs

Searching for new cancer drugs

Researchers used robotic technology and automated microscopy to screen a library of pharmacologically active compound...

TRI establishes new research paradigm for metabolic diseases

TRI establishes new research paradigm for metabolic diseases

Florida Hospital and Sanford-Burnham today celebrate the opening of the Florida Hospital – Sanford-Burnham Translational Research Institute for Metabolism and Diabetes’ (TRI)...

What is “Disease in a Dish?”

What is “Disease in a Dish?”

"Disease in a dish” is a cutting-edge, stem cell-based strategy that allows researchers to study an individual patient’s cells in a laboratory dish...

Our industrial-scale drug discovery capabilities enable scientists at Sanford-Burnham and elsewhere to directly translate their scientific breakthroughs into the medicines of tomorrow.

- Michael Jackson, Ph.D.

Vice President of Drug Discovery and Development

Chemical Genomics at Sanford-Burnham:
Reinventing how new drugs are discovered

Conrad Prebys Center for Chemical GenomicsThe exceptional
translational capabilities
of the Prebys Center

Where do new medicines come from? In the past, large pharmaceutical companies were solely responsible for most drug discovery. Due to high costs and pressures to “fill the pipeline” faster, pharmaceutical companies frequently move away from drug discovery efforts that are deemed risky, especially for “orphan” diseases that are unprofitable for investors. In 2005, the National Institutes of Health announced a 9-year initiative to bridge the gap between basic research carried out in academic research laboratories and FDA approval of new medicines.

The first step in the drug discovery process involves screening small molecules (chemicals) to determine their potential to produce innovative tools for use in biological research. The Conrad Prebys Center for Chemical Genomics screens chemical compounds by the millions to find the few that could potentially be developed into new medicines. All of the results from the Prebys Center's activities are placed into a public database called PubChem, made available to all researchers, in both the public and private sector, for their use in studying biology and disease.

Fully Integrated Translational Capabilities

Partnering to translate basic research into preclinical drug leads

We provide a comprehensive suite of capabilities for preclinical small molecule drug discovery, complete with experienced project management to ensure efficient execution of milestones. The Prebys Center partners with investigators at Sanford-Burnham as well as external parties including those from industry and private foundations and universities.

  • Full-scale capabilities and infrastructure which can provide rapid screening on a broad diversity of assays and detection platforms
  • Several fully integrated industrial-scale high-throughput screening (HTS) workstations
  • HTS microscopy/HCS and novel algorithm development for image analysis
  • Full hit-to-probe chemistry and exploratory pharmacology
  • Powerful NMR based Chemical Fragment Screening
  • Highly integrated informatics infrastructure and efficient data mining capabilities
  • Protein production facility
  • Cell production facility for scale-up tissue culture, including ES and iPSC capabilities
  • Project management

 

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