Xin is interested in the trafficking process of several important Alzheimer's disease (AD) related proteins, such as γ-secretase components, BACE1, APP and Neurotrophin receptors. His main focus is to study the role of a trafficking regulated protein family--Sorting Nexins in neurodevelopment and neurosurvival since several members of this family have already been implicated in the pathogenesis of Alzheimer’s disease. He aims to investigate the influence of some representative members of the family on abnormal brain aging, which may contribute to alleviate the Alzheimer's disease.