Understanding the molecular mechanisms of how free radicals contribute to neurodegenerative conditions.
Dr. Nakamura received his Ph.D. in Biological Sciences from University of Tsukuba, Japan.
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S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.
Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, Lipton SA
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14330-5
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.
Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, Lipton SA
Mol Cell. 2010 Jul 30;39(2):184-95
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.
Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA
Science. 2009 Apr 3;324(5923):102-5
S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease.
Fang J, Nakamura T, Cho DH, Gu Z, Lipton SA
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18742-7
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration.
Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA
Nature. 2006 May 25;441(7092):513-7
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10810-4
Tomohiro Nakamura's Research Focus
Aging-Related Diseases, Alzheimer's Disease, Autism Spectrum Disorders, Huntington's Disease, Neurodegenerative and Neuromuscular Diseases, Parkinson's Disease
Our group is focused on a nitric oxide (NO)-mediated posttranslational modification called S-nitrosylation, whereby an NO group reacts with a critical cysteine thiol of a specific protein to regulate its function, akin to the effect of phosphorylation. Excessive generation of NO in the nervous system may constitute a fundamental pathological process in neurodegenerative disorders, including Alzheimer’s, Parkinson’s, and Huntington’s diseases. Our research is directed towards understanding the molecular mechanisms of how protein S-nitrosylation contributes to mitochondrial dysfunction, protein misfolding, and increased cell death under neurodegenerative conditions.
About Tomohiro Nakamura
Dr. Tomohiro Nakamura received his Ph.D. in Biological Sciences from University of Tsukuba, Japan, where he studied regulatory mechanisms of oxidative stress-induced luteal cell apoptosis. He was a Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow at the Center for Neuroscience, Aging, and Stem Cell Research at the Sanford-Burnham Medical Research Institute, where he has discovered redox-based nitric oxide signaling pathways that lead to neurodegenerative conditions in Alzheimer’s and Parkinson’s diseases. Dr. Nakamura was appointed as a Research Assistant Professor at Sanford-Burnham in 2009.
Postdoctoral, Sanford-Burnham Medical Research Institute Ph.D., University of Tsukuba, Japan B.S., University of Tsukuba, Japan
Funding Awards and Collaborative Grants
2007-2009 Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow for Research Abroad