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Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME
Mol Pharmacol. 2010 Oct;78(4):560-8
Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen.
Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F
J Biomol Screen. 2010 Jul;15(6):663-70
Functional genomic screen for modulators of ciliogenesis and cilium length.
Kim J, Lee JE, Heynen-Genel S, Suyama E, Ono K, Lee K, Ideker T, Aza-Blanc P, Gleeson JG
Nature. 2010 Apr 15;464(7291):1048-51
Statistics of assay validation in high throughput cell imaging of nuclear factor kappaB nuclear translocation.
Morelock MM, Hunter EA, Moran TJ, Heynen S, Laris C, Thieleking M, Akong M, Mikic I, Callaway S, DeLeon RP, Goodacre A, Zacharias D, Price JH
Assay Drug Dev Technol. 2005 Oct;3(5):483-99
Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools.
Price JH, Goodacre A, Hahn K, Hodgson L, Hunter EA, Krajewski S, Murphy RF, Rabinovich A, Reed JC, Heynen S
J Cell Biochem Suppl. 2002;39:194-210
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Susanne Heynen-Genel's Research Focus
Susanne Heynen-Genel has over 15 years of experience in image-based screening systems, including automated microscopy instrumentation, image analysis, algorithm development, and HCS assay design. She has been directing development and execution of image-based high-content assays for high-throughput screening (primary screens of large chemical and RNAi libraries) and small scale screening (secondary assays, focused libraries, assays for validation of basic research findings) for more than 3 years at the CPCCG.
About Susanne Heynen-Genel
Experience
Prior to that she was a staff systems scientist at Beckman Coulter, where her responsibilities included system design and integration of high-content screening systems and applications. Previous to that she was an applications scientist for high-throughput microscopy systems at Q3DM until its acquisition by Beckman Coulter. She spent a year as postdoctoral researcher at the University of California in San Diego where she also received her Ph.D. in Bioengineering in 2002. Her research focused on development and validation of an automated microscopy system followed by its application for cytopathology. This included image analysis, pattern recognition and data mining to take full advantage of the multivariate nature of image-based high-content data.
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