During skeletal muscle differentiation, myogenic bHLH proteins promote the displacement of nucleosomes and generate the landscape conductive to transcriptional activation at muscle loci, through the recruitment of ATP-dependent SWI/SNF chromatin-remodeling complexes. The alternative presence of two catalytic sub-units, either Brg1 or Brm, confers on the SWI/SNF complex the ATPase activity necessary to remodel the chromatin. However, the functional redundancy between Brm and Brg1 is in apparent conflict with their mutually exclusive presence in individual SWI/SNF complexes and suggests that these proteins might play specific roles during skeletal myogenesis. Paula’s goal is to elucidate the individual role of Brm and Brg1-containing SWI/SNF complexes during myoblast differentiation.