Paula Coutinho

  • Research

    Paula’s goal is to elucidate the individual role of Brm and Brg1-containing SWI/SNF complexes during myoblast differentiation.

  • Biography

Publications

 

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Paula Coutino's Research Focus

During skeletal muscle differentiation, myogenic bHLH proteins promote the displacement of nucleosomes and generate the landscape conductive to transcriptional activation at muscle loci, through the recruitment of ATP-dependent SWI/SNF chromatin-remodeling complexes.  The alternative presence of two catalytic sub-units, either Brg1 or Brm, confers on the SWI/SNF complex the ATPase activity necessary to remodel the chromatin. However, the functional redundancy between Brm and Brg1 is in apparent conflict with their mutually exclusive presence in individual SWI/SNF complexes and suggests that these proteins might play specific roles during skeletal myogenesis. Paula’s goal is to elucidate the individual role of Brm and Brg1-containing SWI/SNF complexes during myoblast differentiation.

About Paula Coutino

Experience

Paula recieved her B.S. in Biomedical Sciences from Plinio Leite University, Brazil (2006) and her M.S. in Biosciences from State University of Rio de Janeiro, Brazil (2010). She entered the graduate program in 2011.

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