Developmental myogenesis occurs in successive, asynchronous phases supported by related but intrinsically different myogenic progenitors. These cells ultimately give rise to adult satellite cells, which are essential for postnatal skeletal muscle repair. Matthew is interested in investigating the microenvironmental cues and cell-autonomous features that influence the regenerative potential of these different populations. His work aims to uncover the molecular mechanisms responsible for these characteristics and to use the knowledge gained in developing cell-based therapies designed to treat muscle degenerative diseases.