Matthew Petroski

  • Research

    Dr. Petroski studies how proteins are modified with ubiquitin and ubiquitin-like proteins.

  • Biography

    Dr. Petroski earned his Ph.D. in Biochemistry and Molecular Biology from the University of California, Irvine.

Matthew Petroski's Research Focus

Cancer, Breast Cancer, Leukemia/Lymphoma, Lung Cancer, Myeloma

Our lab focuses on understanding how proteins are modified with ubiquitin and ubiquitin-like proteins. We anticipate that understanding how the ubiquitin system functions and regulates cellular processes will lead to the development of therapeutics that will have broad impact on human health. Alterations in protein function controlled by specific pathways of the ubiquitin system are associated with cancer, inflammation, neurodegenerative diseases, and viral infection. We aim to dissect and study these important pathways using a combination of cell biology, molecular genetics, biochemistry, proteomics, and chemical biology.
 
Our current interests include:
 
1. mechanisms of ubiquitin chain synthesis and protein modification
2. cellular functions of the ubiquitin-like protein NEDD8 in regulating cullin-RING ubiquitin ligases
3. ubiquitinated protein recognition and delivery to the 26S proteasome

About Matthew Petroski

Experience

Matthew Petroski earned his Ph.D. in Biochemistry and Molecular Biology from the University of California, Irvine, and was a Jane Coffin Childs Fellow and HHMI post-doctoral fellow from 1999-2005 with Ray Deshaies at Caltech. From 2005-2007, Matt was a Research Scientist at Rigel Pharmaceuticals, Inc. in South San Francisco and was recruited to Sanford-Burnham Medical Research Institute as an Assistant Professor in December 2007.

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Education

Ph.D., University of California Berkeley, Molecular Biology & Biochemistry, 1999
B.A., University of California, Berkeley, Molecular Cell Biology Genetics, 1993

Honors and Recognition

American Cancer Society Research Scholar
V Foundation for Cancer Research Scholar
Jane Coffin Childs Memorial Fund for Medical Research Fellow

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