Determinants of the Changes in Glycemic Control with Exercise Training in Type 2 Diabetes: A Randomized Trial.
Johannsen NM, Sparks LM, Zhang Z, Earnest CP, Smith SR, Church TS, Ravussin E
PLoS One. 2013;8(6):e62973
Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes.
Sparks LM, Johannsen NM, Church TS, Earnest CP, Moonen-Kornips E, Moro C, Hesselink MK, Smith SR, Schrauwen P
J Clin Endocrinol Metab. 2013 Apr;98(4):1694-702
Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus.
van de Weijer T, Sparks LM, Phielix E, Meex RC, van Herpen NA, Hesselink MK, Schrauwen P, Schrauwen-Hinderling VB
PLoS One. 2013;8(2):e51648
Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity.
Bosma M, Sparks LM, Hooiveld GJ, Jorgensen JA, Houten SM, Schrauwen P, Kersten S, Hesselink MK
Biochim Biophys Acta. 2013 Apr;1831(4):844-52
PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans.
Koves TR, Sparks LM, Kovalik JP, Mosedale M, Arumugam R, DeBalsi KL, Everingham K, Thorne L, Phielix E, Meex RC, Kien CL, Hesselink MK, Schrauwen P, Muoio DM
J Lipid Res. 2013 Feb;54(2):522-34
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.
Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM
Cell. 2012 Jul 20;150(2):366-76
Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes.
Sparks LM, Moro C, Ukropcova B, Bajpeyi S, Civitarese AE, Hulver MW, Thoresen GH, Rustan AC, Smith SR
PLoS One. 2011;6(7):e21068
Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial.
Church TS, Blair SN, Cocreham S, Johannsen N, Johnson W, Kramer K, Mikus CR, Myers V, Nauta M, Rodarte RQ, Sparks L, Thompson A, Earnest CP
JAMA. 2010 Nov 24;304(20):2253-62
Relation of adipose tissue to metabolic flexibility.
Sparks LM, Ukropcova B, Smith J, Pasarica M, Hymel D, Xie H, Bray GA, Miles JM, Smith SR
Diabetes Res Clin Pract. 2009 Jan;83(1):32-43
Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue.
Kaaman M, Sparks LM, van Harmelen V, Smith SR, Sjölin E, Dahlman I, Arner P
Diabetologia. 2007 Dec;50(12):2526-33
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.
Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR
Diabetes. 2005 Jul;54(7):1926-33
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Reduced incorporation of fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes.
Sparks LM, Bosma M, Brouwers B, van de Weijer T, Bilet L, Schaart G, Moonen-Kornips E, Eichmann TO, Lass A, Hesselink MK, Schrauwen P
Diabetes. 2014 May;63(5):1583-93
Lauren Sparks's Research Focus
As a Faculty Scientist at the Translational Research Institute for Metabolism and Diabetes (TRI), Dr. Lauren Sparks conducts her work in the area of exercise and muscle metabolism. She is currently pursuing investigations on the topics of “exercise resistance”, as well as the ‘good’ and ‘bad’ communication between fat and muscle. Dr. Sparks is interested in understanding why some individuals do not respond favorably to exercise as a means of improving their metabolism and related co-morbidities. She aims to advance the field of exercise and type 2 diabetes and potentially shift the paradigm, allowing interventions to be targeted to those individuals most likely to benefit as well as identify novel approaches to treat those who do not. Dr. Sparks is also interested in understanding the communication between muscle and fat tissue and how some individuals who are obese, but metabolically healthy, differ from those individuals who are obese and metabolically unhealthy.
About Lauren Sparks
Prior to joining the TRI, Dr. Sparks was a postdoctoral scientist at Maastricht University in the Netherlands from 2009-2012. In her time at Maastricht University, Dr. Sparks pursued a rigorous training in understanding the connections between exercise and the function of mitochondria, which are the tiny “power houses” of the cell that are responsible for converting fat and carbohydrate into energy. Dr. Sparks was extremely productive in her time at Maastricht University and had several successful publications in top tier journals.
From 2006-2009, Dr. Sparks was a postdoctoral fellow at Pennington Biomedical Research Center in Baton Rouge, Louisiana. She received a training fellowship from the National Institutes of Health (NIH) in 2007 and conducted a clinical exercise trial that investigated the effects of different types of exercise on the ability of the muscle to burn fat and carbohydrate more efficiently in men and women with type 2 diabetes.
Dr. Lauren Sparks was born in Patterson, Louisiana. She earned a B.S. in Zoology and a B.A. in Spanish in 2002 and continued on to earn her PhD in Biological Sciences, with a concentration in molecular biology, in 2006 from Louisiana State University.