How the genome is controlling metabolism and how fatty signaling molecules via nuclear hormone receptors change cell fate and function.
M.D. University of Debrecen, School of Medicine 1991 Ph.D. University of Debrecen 1995
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The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.
Daniel B, Nagy G, Hah N, Horvath A, Czimmerer Z, Poliska S, Gyuris T, Keirsse J, Gysemans C, Van Ginderachter JA, Balint BL, Evans RM, Barta E, Nagy L
Genes Dev. 2014 Jul 15;28(14):1562-77
Laszlo Nagy's Research Focus
Dr. Nagy is a physician by training and a molecular and cell biologist with a long-standing research interest in the biology of gene-expression regulation, cellular differentiation, and their contribution to human diseases. The fundamental question he raises in his research is how lipid signaling regulates gene expression and how a changing extra- and intracellular lipid environment impacts the expression of the genome and contributes to changing cellular phenotypes. He uses the paradigm of nuclear hormone receptor activation/signaling and the contribution of this process to myeloid cell differentiation, function, and to diseases, involving these cells, such as atherosclerosis, tissue regeneration, metabolic, and various inflammatory disorders, as his model systems. He uses genome-wide and epigenomic approaches along with bioinformatics and data integration.
About Laszlo Nagy
Dr Nagy is a physician scientist and a cell and molecular biologist. He obtained an M.D. and subsequently a Ph.D. from the University of Debrecen, Hungary. He has carried out two post-doctoral training periods at the UNiversity of Texas-Houston and later at the Salk Institute in San Diego.