Jamey Marth, Ph.D.
A holistic and rigorous integration of multiple disciplines is required to perceive and most effectively manipulate the mechanisms of health and disease. Sanford-Burnham Medical Research Institute facilitates this discovery process by supporting frontiers in research and technology programs, the development of interdisciplinary expertise, and a healthy skepticism of current dogma.
Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.
Dr. Marth received a Ph.D. degree in Pharmacology from the University of Washington.
Dual roles for hepatic lectin receptors in the clearance of chilled platelets.
Rumjantseva V, Grewal PK, Wandall HH, Josefsson EC, Sørensen AL, Larson G, Marth JD, Hartwig JH, Hoffmeister KM
Nat Med. 2009 Nov;15(11):1273-80
Mammalian glycosylation in immunity.
Marth JD, Grewal PK
Nat Rev Immunol. 2008 Nov;8(11):874-87
A unified vision of the building blocks of life.
Nat Cell Biol. 2008 Sep;10(9):1015-6
The Ashwell receptor mitigates the lethal coagulopathy of sepsis.
Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD
Nat Med. 2008 Jun;14(6):648-55
Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.
Green RS, Stone EL, Tenno M, Lehtonen E, Farquhar MG, Marth JD
Immunity. 2007 Aug;27(2):308-20
Glycosylation in cellular mechanisms of health and disease.
Ohtsubo K, Marth JD
Cell. 2006 Sep 8;126(5):855-67
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
Grewal PK, Boton M, Ramirez K, Collins BE, Saito A, Green RS, Ohtsubo K, Chui D, Marth JD
Mol Cell Biol. 2006 Jul;26(13):4970-81
Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes.
Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD
Cell. 2005 Dec 29;123(7):1307-21
Unmasking connections in transmembrane immune signaling.
Nat Immunol. 2004 Oct;5(10):1008-10
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Deficiency of the Sialyltransferase St3Gal4 Reduces Ccl5-Mediated Myeloid Cell Recruitment and Arrest.
Döring Y, Noels H, Mandl MM, Kramp B, Neideck C, Lievens D, Drechsler M, Megens RT, Tilstam PV, Langer M, Hartwig H, Theelen W, Marth JD, Sperandio M, Soehnlein O, Weber C
Circ Res. 2014 Jan 14;
Jamey Marth's Research Focus
Cancer, Leukemia/Lymphoma, Lung Cancer, Cardiovascular Diseases, Atherosclerosis, Peripheral Vascular Disease, Infectious Diseases, Inflammatory/Autoimmune Disease, Arthritis, Crohn’s Disease (Colitis), Systemic Lupus Erythematosus, Metabolic Diseases, Type 1 Diabetes, Type 2 Diabetes, Neurodegenerative and Neuromuscular Diseases, Multiple Sclerosis, Spinal Cord Injury
The Marth laboratory develops and applies new technologies to discover the origins and mechanisms of disease. This has included the development of Cre-loxP conditional mutagenesis, a technique now used by researchers throughout the world to interrogate gene activity in normal and disease processes. Using a combination of such methodological advances applied to cellular biology and mammalian physiology, the Marth laboratory has discovered unexpected key roles of protein glycosylation in the mechanisms of health and disease. More recently, the Marth laboratory is incorporating microfluidic, and microarray platforms to develop high-throughput sensors that would enable the integrative analysis of the four fundamental components of all cells, namely the nucleic acids, proteins, lipids, and glycans, which operate together to govern health and disease.
Research projects span molecular and cellular biology, as well as animal physiology, and are relevant to understanding the origins of diabetes, autoimmune diseases, cancer, the complications of infectious disease, and neurological dysfunction. Research in the Marth laboratory has discovered pathogenic and molecular mechanisms that cause dietary- and obesity-associated diabetes, inflammation, systemic lupus erythematosus, and the lethal complications of infection that include sepsis and coagulopathy. These findings further indicate that there exist biomarkers and causes of disease for which no relevant diagnostics or therapeutics presently exist. The Marth laboratory is applying these discoveries towards the development of novel diagnostics for basic and applied research, as well as therapeutics that precisely target the pathophysiological origins of disease in order to most effectively achieve disease prevention, treatment, and ultimately cure.
About Jamey Marth
Jamey Marth is a Professor of the University of California, Santa Barbara and of the Sanford-Burnham Medical Research Institute. Dr. Marth is the inaugural holder of the John Carbon Endowed Chair of Biochemistry and Molecular Biology and the Duncan and Suzanne Mellichamp Endowed Chair of Systems Biology at UC Santa Barbara. Dr. Marth is also a faculty member of the Department of Molecular, Cellular, and Developmental Biology, and a member of the Biomolecular Science and Engineering program at UC Santa Barbara. He received a Ph.D. degree in Pharmacology from the University of Washington in Seattle and studied in the laboratories of Dr. Roger M. Perlmutter, currently Executive Vice-President of Research and Development at Amgen; and the late Dr. Edwin G. Krebs, a 1992 Nobel laureate in Physiology or Medicine and Professor Emeritus at University of Washington in Seattle. Dr. Marth was recruited to UC San Diego in 1995 by Dr. George Palade, whom was a 1974 Nobel laureate in Physiology or Medicine. Dr. Marth was an Investigator of the Howard Hughes Medical Institute and Professor in the Department of Cellular and Molecular Medicine at UC San Diego prior to his current position.
Ph.D., University of Washington, Pharmacology, 1987
B.S., University of Oregon, Genetics and Chemistry, 1984
Professor and Riector, UCSB-SBMRI Center for Nanomedicine
John Carbon Chair of Biochemistry and Molecular Biology
Duncan and Suzanne Mellichamp Chair of Systems Biology
Department of Molecular, Cellular, and Developmental Biology
Biomolecular Science and Engineering program
University of California, Santa Barbara
Honors and Recognition
John Carbon Chair in Biochemistry and Molecular Biology, 2009 - Pres.
Duncan and Suzanne Mellichamp Chair in Systems Biology, 2009 - Pres.
Investigator, Howard Hughes Medical Institute, 1995 - 2009
University of California San Diego, Professor, 1999 - 2009
Faculty Scholarship, The Medical Research Council of Canada, 1991 - 1995