Prostate stem cells (PSCs) functions in glandular development and maintenance. Giuseppina is interested in define specific markers for normal prostate stem cells (PSCs) applying new methods. Several cells surfaces markers have been reported to identify candidate PSCs, including stem cell sntigen-1 (Sca1), CD49f, tumor-associated calcium signal transducer 2 (Trop2), CD133, CD44, and CD117. However many non PSCs in the mouse and human prostate also express these markers and thus identification of a defined PSC population remains elusive. Since the critical role of PSCs in maintaining prostate tissue integrity and their potential involvement in prostate tumorigenesis, Giuseppina investigates how to isolate PSC to study the molecular profiling and delineate mechanisms that regulate their self renewal and differentiation.