Gabriel Guerrero

  • Research

    Gabriel’s research focuses on the role of (ER) stress and the (UPR) in the function and homeostasis of intestinal epithelial cells (IECs).

  • Biography

    Gabriel earned a Bachelor of Arts in Economics and Biology at San Diego State University. He began his graduate studies in 2013.

Publications

 

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Gabriel Guerrero's Research Focus

Gabriel’s research focuses on the role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in the function and homeostasis of intestinal epithelial cells (IECs). When ER protein folding is perturbed, or cells are stimulated to secrete large amounts of protein, unfolded/misfolded proteins accumulate in the ER lumen, a condition called ER stress. In order to restore ER function and protein homeostasis, eukaryotes have evolved the unfolded protein response. In mammalian cells, the UPR is initiated by three ER-localized transmembrane protein sensors: activating transcription factor 6 (ATF6), inositol-requiring kinase 1 (IRE1) and PKR-like ER kinase (PERK). By further elucidating the role of ER stress and the UPR in IECs, Gabriel hopes to better understand the fundamental mechanisms that contribute to the pathogenesis of inflammatory bowel diseases.

About Gabriel Guerrero

Experience

Gabriel earned a Bachelor of Arts in Economics and Biology at San Diego State University. He began his graduate studies in 2013.

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