Duc Dong

Duc Dong, Ph.D.[La Jolla]

If we understand the developmental biology, then we might be able to replicate it. Also, with an understanding of the regenerative pathway, we may have therapeutic targets where you add a drug or apply gene therapy to encourage the body to regenerate the cells.

  • Research

    Dr. Dong’s group is working to decipher progenitor biology to gain insight into development and disease.

  • Biography

    Dr. Dong earned his Ph.D. in Cell and Molecular Biology at the University of Wisconsin, Madison in 2002.

Publications

 

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Duc Dong's Research Focus

Colorectal Cancer, Type 1 Diabetes, Type 2 Diabetes, Liver Cancer, Pancreatic Cancer, Monogenic Diabetes

The Dong laboratory is primarily focused on understanding progenitor biology. Their goal is to decipher progenitor biology to the point that will allow us to genetically or pharmacologically manipulate differentiation in vivo, which will undoubtedly advance the field of regenerative medicine.
The Dong laboratory aims to gain insight into diseases associated progenitor dysfunction and their potential therapies. Using the zebrafish vertebrate model system, we are currently researching how transcription and signaling factors regulate progenitors of the pancreas, liver, and intestine.

Duc Dong's Research Report

Duc Dong
We are interested in diseases associated with the endoderm and progenitor biology, particularly diabetes and cancers of liver, pancreas, and colon. Loss of the insulin producing pancreatic ß-cells is characteristic of nearly all forms of diabetes and is the underlying factor for diabetic insulin dependence. Elucidation of the mechanisms of genes implicated in diabetes and ß-cell development will profoundly contribute to our understanding of diabetes etiology and to ongoing efforts to engineer therapeutic replacement ß-cells. Many cancer stem cells have been shown to express developmental progenitor genes. Understanding the function of these genes during normal development will yield critical insight into their roles in regulating cancer stem cells.


Technology

To accelerate and improve the quality of progenitor and stem cell research, we are developing new genetic tools that will allow us to measure and manipulate gene function in vivo, in a more precise spatiotemporally manner. We are combining genetic techniques available in other genetic model systems such as mice, flies and yeast, with those in zebrafish to generate new approaches to studying gene function. These technologies will necessary for more rigorous investigations of the function of genes involved in development and disease.



About Duc Dong

Experience

Duc Si Dong earned his Ph.D. in Cell and Molecular Biology at the University of Wisconsin, Madison in 2002. After postdoctoral training at the University of California, San Francisco in the laboratory of Dr. Didier Stainier, Dr. Dong was recruited to Sanford-Burnham Medical Research Institute in 2008.

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Education

University of California, Irvine, B.S., Biology
University of Wisconsin, Madison, Ph.D., Cell & Molecular Biology
University of California, San Francisco, Postdoctoral Fellow, Genetics and Development

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