The broad classification of disease subtypes, such as Type 2 Diabetes, often masks their mechanistic heterogeneity as well as their potential similarities. By recognizing and understanding a patient’s disease subtype based on a particular genetic mechanism, we will be better able to align more targeted and precise drugs and therapeutics to an individual’s specific disease etiology.
Dr. Dong’s group is working to decipher progenitor biology to gain insight into development and disease.
Dr. Dong earned his Ph.D. in Cell and Molecular Biology at the University of Wisconsin, Madison in 2002.
View All Publications
An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment.
Lin N, Chang KY, Li Z, Gates K, Rana ZA, Dang J, Zhang D, Han T, Yang CS, Cunningham TJ, Head SR, Duester G, Dong PD, Rana TM
Mol Cell. 2014 Mar 20;53(6):1005-19
Duc Dong's Research Focus
Colorectal Cancer, Type 1 Diabetes, Type 2 Diabetes, Liver Cancer, Pancreatic Cancer, Monogenic Diabetes
Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the genetic mechanisms governing organogenesis and disease. His laboratory has discovered multiple genes critical for lineage specification of liver and pancreas progenitors and is developing several animal models of diabetes that will be amendable for in vivo drug screens.
About Duc Dong
Dr. Dong was recruited as an Assistant Professor to Sanford-Burnham Medical Research Institute in 2008 to continue his research in developmental genetics and disease. His lab has developed the first zebrafish monogenic diabetes model and is continuing to develop other disease models that will be amendable for drug discovery. He is a recipient of the NIH Director’s New Innovator Award, which funds the adaptation of a new genetic mosaic technology developed by his lab towards the reprogramming of new cell and organ formation within a living vertebrate.
University of California, Irvine, B.S., Biology
University of Wisconsin, Madison, Ph.D., Cell & Molecular Biology
University of California, San Francisco, Postdoctoral Fellow, Genetics and Development