If we understand the developmental biology, then we might be able to replicate it. Also, with an understanding of the regenerative pathway, we may have therapeutic targets where you add a drug or apply gene therapy to encourage the body to regenerate the cells.
Dr. Dong’s group is working to decipher progenitor biology to gain insight into development and disease.
Dr. Dong earned his Ph.D. in Cell and Molecular Biology at the University of Wisconsin, Madison in 2002.
View All Publications
Regulation of neurocoel morphogenesis by Pard6 gamma b.
Munson C, Huisken J, Bit-Avragim N, Kuo T, Dong PD, Ober EA, Verkade H, Abdelilah-Seyfried S, Stainier DY
Dev Biol. 2008 Dec 1;324(1):41-54
Organ-specific requirements for Hdac1 in liver and pancreas formation.
Noël ES, Casal-Sueiro A, Busch-Nentwich E, Verkade H, Dong PD, Stemple DL, Ober EA
Dev Biol. 2008 Oct 15;322(2):237-50
Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.
Dong PD, Provost E, Leach SD, Stainier DY
Genes Dev. 2008 Jun 1;22(11):1445-50
Fgf10 regulates hepatopancreatic ductal system patterning and differentiation.
Dong PD, Munson CA, Norton W, Crosnier C, Pan X, Gong Z, Neumann CJ, Stainier DY
Nat Genet. 2007 Mar;39(3):397-402
Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis.
Ng AN, de Jong-Curtain TA, Mawdsley DJ, White SJ, Shin J, Appel B, Dong PD, Stainier DY, Heath JK
Dev Biol. 2005 Oct 1;286(1):114-35
Formation of the digestive system in zebrafish. II. Pancreas morphogenesis.
Field HA, Dong PD, Beis D, Stainier DY
Dev Biol. 2003 Sep 1;261(1):197-208
Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes.
Dong PD, Todi SV, Eberl DF, Boekhoff-Falk G
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10293-8
Distal-less and homothorax regulate multiple targets to pattern the Drosophila antenna.
Dong PD, Dicks JS, Panganiban G
Development. 2002 Apr;129(8):1967-74
Limb type-specific regulation of bric a brac contributes to morphological diversity.
Chu J, Dong PD, Panganiban G
Development. 2002 Feb;129(3):695-704
Proximodistal domain specification and interactions in developing Drosophila appendages.
Dong PD, Chu J, Panganiban G
Development. 2001 Jun;128(12):2365-72
Duc Dong's Research Focus
Colorectal Cancer, Type 1 Diabetes, Type 2 Diabetes, Liver Cancer, Pancreatic Cancer, Monogenic Diabetes
The Dong laboratory is primarily focused on understanding progenitor biology. Their goal is to decipher progenitor biology to the point that will allow us to genetically or pharmacologically manipulate differentiation in vivo, which will undoubtedly advance the field of regenerative medicine.
The Dong laboratory aims to gain insight into diseases associated progenitor dysfunction and their potential therapies. Using the zebrafish vertebrate model system, we are currently researching how transcription and signaling factors regulate progenitors of the pancreas, liver, and intestine.
Duc Dong's Research Report
We are interested in diseases associated with the endoderm and progenitor biology, particularly diabetes and cancers of liver, pancreas, and colon. Loss of the insulin producing pancreatic ß-cells is characteristic of nearly all forms of diabetes and is the underlying factor for diabetic insulin dependence. Elucidation of the mechanisms of genes implicated in diabetes and ß-cell development will profoundly contribute to our understanding of diabetes etiology and to ongoing efforts to engineer therapeutic replacement ß-cells. Many cancer stem cells have been shown to express developmental progenitor genes. Understanding the function of these genes during normal development will yield critical insight into their roles in regulating cancer stem cells.
To accelerate and improve the quality of progenitor and stem cell research, we are developing new genetic tools that will allow us to measure and manipulate gene function
, in a more precise spatiotemporally manner. We are combining genetic techniques available in other genetic model systems such as mice, flies and yeast, with those in zebrafish to generate new approaches to studying gene function. These technologies will necessary for more rigorous investigations of the function of genes involved in development and disease.
About Duc Dong
Duc Si Dong earned his Ph.D. in Cell and Molecular Biology at the University of Wisconsin, Madison in 2002. After postdoctoral training at the University of California, San Francisco in the laboratory of Dr. Didier Stainier, Dr. Dong was recruited to Sanford-Burnham Medical Research Institute in 2008.
University of California, Irvine, B.S., Biology
University of Wisconsin, Madison, Ph.D., Cell & Molecular Biology
University of California, San Francisco, Postdoctoral Fellow, Genetics and Development