Dr. Osterman’s research team uses a systems-biology approach to reconstruct and explore metabolic and transcriptional regulatory networks.
Dr. Osterman received his Ph.D. from Moscow State University in 1983
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Functional specialization in proline biosynthesis of melanoma.
De Ingeniis J, Ratnikov B, Richardson AD, Scott DA, Aza-Blanc P, De SK, Kazanov M, Pellecchia M, Ronai Z, Osterman AL, Smith JW
PLoS One. 2012;7(9):e45190
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.
Filipp FV, Scott DA, Ronai ZA, Osterman AL, Smith JW
Pigment Cell Melanoma Res. 2012 May;25(3):375-83
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.
Scott DA, Richardson AD, Filipp FV, Knutzen CA, Chiang GG, Ronai ZA, Osterman AL, Smith JW
J Biol Chem. 2011 Dec 9;286(49):42626-34
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis.
Sorci L, Martynowski D, Rodionov DA, Eyobo Y, Zogaj X, Klose KE, Nikolaev EV, Magni G, Zhang H, Osterman AL
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3083-8
Genomic reconstruction of Shewanella oneidensis MR-1 metabolism reveals a previously uncharacterized machinery for lactate utilization.
Pinchuk GE, Rodionov DA, Yang C, Li X, Osterman AL, Dervyn E, Geydebrekht OV, Reed SB, Romine MF, Collart FR, Scott JH, Fredrickson JK, Beliaev AS
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2874-9
A novel class of modular transporters for vitamins in prokaryotes.
Rodionov DA, Hebbeln P, Eudes A, ter Beek J, Rodionova IA, Erkens GB, Slotboom DJ, Gelfand MS, Osterman AL, Hanson AD, Eitinger T
J Bacteriol. 2009 Jan;191(1):42-51
PMAP: databases for analyzing proteolytic events and pathways.
Igarashi Y, Heureux E, Doctor KS, Talwar P, Gramatikova S, Gramatikoff K, Zhang Y, Blinov M, Ibragimova SS, Boyd S, Ratnikov B, Cieplak P, Godzik A, Smith JW, Osterman AL, Eroshkin AM
Nucleic Acids Res. 2009 Jan;37(Database issue):D611-8
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Rodionov DA, Li X, Rodionova IA, Yang C, Sorci L, Dervyn E, Martynowski D, Zhang H, Gelfand MS, Osterman AL
Nucleic Acids Res. 2008 Apr;36(6):2032-46
Transcriptional regulation of NAD metabolism in bacteria: NrtR family of Nudix-related regulators.
Rodionov DA, De Ingeniis J, Mancini C, Cimadamore F, Zhang H, Osterman AL, Raffaelli N
Nucleic Acids Res. 2008 Apr;36(6):2047-59
Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism.
Huang N, Sorci L, Zhang X, Brautigam CA, Li X, Raffaelli N, Magni G, Grishin NV, Osterman AL, Zhang H
Structure. 2008 Feb;16(2):196-209
Glycerate 2-kinase of Thermotoga maritima and genomic reconstruction of related metabolic pathways.
Yang C, Rodionov DA, Rodionova IA, Li X, Osterman AL
J Bacteriol. 2008 Mar;190(5):1773-82
Central carbon metabolism in the progression of mammary carcinoma.
Richardson AD, Yang C, Osterman A, Smith JW
Breast Cancer Res Treat. 2008 Jul;110(2):297-307
CutDB: a proteolytic event database.
Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW, Osterman AL, Godzik A
Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9
Andrei Osterman's Research Focus
Breast Cancer, Infectious Diseases, Skin Cancer and Melanoma, Radiation Damage
Watch Dr. Osterman describe his research
The main focus of Dr. Osterman’s research team is on fundamental and applied aspects of the key metabolic subsystems in a variety of species, from bacteria to human. This group uses a Systems Biology approach to reconstruct and explore metabolic and transcriptional regulatory networks. This approach combines comparative genomics and other bioinformatic techniques with biochemical and genetic experiments for pathway, gene and target discovery. Using this approach this group predicted and experimentally verified numerous enzyme families in the metabolism of cofactors, carbohydrates, and amino acids. Recent breakthroughs included prediction and characterization of novel transporters, transcriptional regulators and carbohydrate utilization pathways in a number of model bacterial systems. Applications in the field of infectious disease include identification of novel drug targets and structure-based development of novel antiinfective agents. New directions in cancer research are based on application of metabolic profiling technology for identification of novel diagnostic and therapeutic targets. Other directions of the on-going research include bioinformatics of regulatory proteolysis and applications of structural modeling for exploration of metabolic networks and gene discovery.
About Andrei Osterman
Andrei Osterman is an Associate Professor in the Bioinformatics and Systems Biology Program at the Infectious and Inflammatory Disease Center of Sanford-Burnham Medical Research Institute (since August 2003). He received his doctorate from Moscow State University in 1983, did postdoctoral work UT Southwestern Medical Center, and held the position of the Director and then Vice President of Research at Integrated Genomics in 1999-2003. Dr. Osterman is one of the founders of the Fellowship for Interpretation of Genomes (FIG), a nonprofit research organization that launched the Project to Annotate 1,000 Genomes in 2003. FIG provides the open-source integration of all publicly available genomes and tools for their comparative analysis, annotation, and metabolic reconstruction.