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Research
Dr. Terskikh is interested in elucidating the mechanisms underlying self-renewing & differentiation decisions in normal & cancer stem cells.
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Biography
Dr. Terskikh earned his Ph.D. at the University of Lausanne, Switzerland in 1996.
Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory.
Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour GJ, Enikolopov G, Roberts AJ, Terskikh AV
J Neurosci. 2011 Jul 6;31(27):9933-44
Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis.
Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV
Cell Stem Cell. 2011 May 6;8(5):538-51
Early acquisition of neural crest competence during hESCs neuralization.
Curchoe CL, Maurer J, McKeown SJ, Cattarossi G, Cimadamore F, Nilbratt M, Snyder EY, Bronner-Fraser M, Terskikh AV
PLoS One. 2010;5(11):e13890
Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo.
Hebbard LW, Maurer J, Miller A, Lesperance J, Hassell J, Oshima RG, Terskikh AV
Cancer Res. 2010 Nov 1;70(21):8863-73
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide.
Belousov VV, Fradkov AF, Lukyanov KA, Staroverov DB, Shakhbazov KS, Terskikh AV, Lukyanov S
Nat Methods. 2006 Apr;3(4):281-6
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7934-9
"Fluorescent timer": protein that changes color with time.
Terskikh A, Fradkov A, Ermakova G, Zaraisky A, Tan P, Kajava AV, Zhao X, Lukyanov S, Matz M, Kim S, Weissman I, Siebert P
Science. 2000 Nov 24;290(5496):1585-8
Recent Options
SOX2 modulates levels of MITF in normal human melanocytes, and melanoma lines in vitro.
Cimadamore F, Shah M, Amador-Arjona A, Navarro-Peran E, Chen C, Huang CT, Terskikh AV
Pigment Cell Melanoma Res. 2012 Jul;25(4):533-6
[Differential and morphogenetic potential of rat dermal papilla cells].
Gnedeva KIu, Voroteliak EA, Terskikh AV, Vasil'ev AV, Terskikh VV
Izv Akad Nauk Ser Biol. 2011 Nov-Dec;(6):653-8
hESC derived neuro-epithelial rosettes recapitulate early mammalian neurulation events; an in vitro model.
Curchoe CL, Russo J, Terskikh AV
Stem Cell Res. 2012 Mar;8(2):239-46
MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.
Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton SA
PLoS One. 2011;6(8):e24027
Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory.
Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour GJ, Enikolopov G, Roberts AJ, Terskikh AV
J Neurosci. 2011 Jul 6;31(27):9933-44
DMSO-Free Programmed Cryopreservation of Fully Dissociated and Adherent Human Induced Pluripotent Stem Cells.
Katkov II, Kan NG, Cimadamore F, Nelson B, Snyder EY, Terskikh AV
Stem Cells Int. 2011;2011:981606
Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis.
Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV
Cell Stem Cell. 2011 May 6;8(5):538-51
Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination.
Crocker SJ, Bajpai R, Moore CS, Frausto RF, Brown GD, Pagarigan RR, Whitton JL, Terskikh AV
Neuropathol Appl Neurobiol. 2011 Oct;37(6):643-53
Early acquisition of neural crest competence during hESCs neuralization.
Curchoe CL, Maurer J, McKeown SJ, Cattarossi G, Cimadamore F, Nilbratt M, Snyder EY, Bronner-Fraser M, Terskikh AV
PLoS One. 2010;5(11):e13890
Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo.
Hebbard LW, Maurer J, Miller A, Lesperance J, Hassell J, Oshima RG, Terskikh AV
Cancer Res. 2010 Nov 1;70(21):8863-73
View All Publications
Alexey Terskikh's Research Focus
Brain Cancer, Breast Cancer, Parkinson's Disease
During development and in many adult tissues stem cells are capable of self-renewal or differentiation depending on the extrinsic signals provided by surrounding (e.g. the stem cell niche). Many cancers are thought to be maintained by cancer initiating cells (sometimes called cancer stem cells), which are often hijack stem cell self-renewal mechanisms. The Terskikh laboratory is interested in elucidating molecular and cellular mechanisms underlying self-renewing and differentiation decisions using neural stem cells as a model, in particularly studying how this knowledge can be used to fight cancer.
About Alexey Terskikh
Experience
Alexey Terskikh earned his Ph.D. at the University of Lausanne, Switzerland in 1996, in the laboratory of Prof. J.-P. Mach, where he designed a new type of high-avidity recombinant molecule called Peptabody. He received postdoctoral training with Prof. Irving Weissman at Stanford University, where he discovered a common genetic program between hematopoietic and neural stem cells. Dr. Terskikh holds an Assistant Professor position in the Brain and Mind Institute at EPFL in Lausanne, Switzerland (2002-2006) and was recruited to Sanford-Burnham Medical Research Institute as Adjunct Assistant Professor in 2002 and as a full time Assistant Professor in 2006.
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