Dr. Sacco is investigating the self-renewal mechanism of skeletal muscle stem cells.
Alessandra Sacco completed her studies at La Sapienza University in Rome, Italy.
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Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture.
Gilbert PM, Havenstrite KL, Magnusson KE, Sacco A, Leonardi NA, Kraft P, Nguyen NK, Thrun S, Lutolf MP, Blau HM
Science. 2010 Aug 27;329(5995):1078-81
Reprogramming towards pluripotency requires AID-dependent DNA demethylation.
Bhutani N, Brady JJ, Damian M, Sacco A, Corbel SY, Blau HM
Nature. 2010 Feb 25;463(7284):1042-7
A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches.
Cosgrove BD, Sacco A, Gilbert PM, Blau HM
Differentiation. 2009 Sep-Oct;78(2-3):185-94
Self-renewal and expansion of single transplanted muscle stem cells.
Sacco A, Doyonnas R, Kraft P, Vitorovic S, Blau HM
Nature. 2008 Nov 27;456(7221):502-6
IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors.
Sacco A, Doyonnas R, LaBarge MA, Hammer MM, Kraft P, Blau HM
J Cell Biol. 2005 Nov 7;171(3):483-92
Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors.
Doyonnas R, LaBarge MA, Sacco A, Charlton C, Blau HM
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13507-12
Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons.
Amadoro G, Serafino AL, Barbato C, Ciotti MT, Sacco A, Calissano P, Canu N
Cell Death Differ. 2004 Feb;11(2):217-30
HPV E7 expression in skeletal muscle cells distinguishes initiation of the postmitotic state from its maintenance.
Sacco A, Siepi F, Crescenzi M
Oncogene. 2003 Jun 26;22(26):4027-34
Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry.
Bonapace IM, Latella L, Papait R, Nicassio F, Sacco A, Muto M, Crescenzi M, Di Fiore PP
J Cell Biol. 2002 Jun 10;157(6):909-14
Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle.
Latella L, Sacco A, Pajalunga D, Tiainen M, Macera D, D'Angelo M, Felici A, Sacchi A, Crescenzi M
Mol Cell Biol. 2001 Aug;21(16):5631-43
Alessandra Sacco's Research Focus
Childhood Diseases, Muscular Dystrophy, Sarcopenia/Aging-Related Muscle Atrophy
Skeletal muscle wasting is a devastating pathology that occurs in several human conditions, including muscular dystrophies, aging, HIV. There is currently no cure for it. Muscle stem cells offer great promise for future therapies, but their use is currently limited by our poor understanding of the regulatory mechanisms directing their behavior. We are interested in understanding how extrinsic and intrinsic factors regulate muscle stem cells in vivo. Current projects include: (1) Developing stem cell-based strategies for treating muscle wasting diseases, (2) Understanding how aging affects the muscle stem cell compartment.
About Alessandra Sacco
Alessandra Sacco completed her studies at La Sapienza University in Rome, Italy. In 2002 Dr. Sacco joined the laboratory of Prof. Helen M. Blau at Stanford University as a postdoctoral fellow (2002-2009), where she studied cell fusion between hematopoietic cells and muscle cells, as a potential mechanism for tissue repair. Recently she defined strategies to isolate adult skeletal muscle stem cells and performed single cell transplantation experiments, providing the first definitive evidence that adult muscle stem cells are able to self-renew in vivo. She received research funding from Muscular Dystrophy Association (2006-2008). In 2010 Dr. Sacco was recruited as Assistant Professor at Sanford-Burnham Medical Research Institute.