Dr. Godzik's research focuses on biological systems and their evolution.
Dr. Adam Godzik earned his Ph.D. in physics from the Department of Physics, University of Warsaw, Poland in 1990.
e-Driver: a novel method to identify protein regions driving cancer.
Porta-Pardo E, Godzik A
Bioinformatics. 2014 Jul 26;
Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli.
Chang RL, Andrews K, Kim D, Li Z, Godzik A, Palsson BO
Science. 2013 Jun 7;340(6137):1220-3
Evolution of the animal apoptosis network.
Zmasek CM, Godzik A
Cold Spring Harb Perspect Biol. 2013 Mar;5(3):a008649
This Déjà vu feeling--analysis of multidomain protein evolution in eukaryotic genomes.
Zmasek CM, Godzik A
PLoS Comput Biol. 2012;8(11):e1002701
Strong functional patterns in the evolution of eukaryotic genomes revealed by the reconstruction of ancestral protein domain repertoires.
Zmasek CM, Godzik A
Genome Biol. 2011;12(1):R4
Three-dimensional structural view of the central metabolic network of Thermotoga maritima.
Zhang Y, Thiele I, Weekes D, Li Z, Jaroszewski L, Ginalski K, Deacon AM, Wooley J, Lesley SA, Wilson IA, Palsson B, Osterman A, Godzik A
Science. 2009 Sep 18;325(5947):1544-9
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.
Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA
Science. 2009 Apr 3;324(5923):102-5
Comparison of sequence profiles. Strategies for structural predictions using sequence information.
Rychlewski L, Jaroszewski L, Li W, Godzik A
Protein Sci. 2000 Feb;9(2):232-41
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Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications.
Chiu HJ, Grant JC, Farr CL, Jaroszewski L, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
Acta Crystallogr D Biol Crystallogr. 2014 Oct 1;70(Pt 10):2640-51
Adam Godzik's Research Focus
Our research is focused on biological systems and their evolution. We try to combine insights from mathematics and physics to answer basic questions about biological systems and to use them to develop new computational tools that could allow us to find new regularities and trends in biological data. In particular we are trying to understand how the topology, structure, and function of proteins and protein networks has evolved and how it reacts to perturbation, such as disease mutations or other genomics perturbations.
By combining structural information about proteins with data on cellular networks formed by these proteins in an approach we call structural systems biology we can explicitly model the networks in their perturbed state and try to predict their behavior. We study systems from bacterial metabolic and virulence networks, to human immunity, apoptosis and cancer networks.
Adam Godzik's Research Report
Adam Godzik - website
is a database that unites information on somatic missense mutations from TCGA and CCLE, allowing users to explore two different cancer-related problems at the same time: drug sensitivity/biomarker identification and prediction of cancer drivers. The database is an interface to two novel algorithms, e-Driver and e-Drug, that make use of information about the internal structure of a protein to predict novel cancer drivers or drug biomarkers respectively. Moreover, it maps somatic missense mutations from over 18,000 human proteins to more than 25,000 protein structures from PDB.
About Adam Godzik
Dr. Adam Godzik earned his Ph.D. in physics from the Department of Physics, University of Warsaw, Poland in 1990. After postdoctoral work in the European Molecular Biology Laboratory in Heidelberg and The Scripps Research Institute in San Diego, he became an Assistant Professor at The Scripps Research Institute. In 1999 he joined Sanford-Burnham Medical Research Institute as an Associate Professor.