Dr. Godzik's research is focused on proteins, their sequences, structures and functions, and the relationships between the three.
Dr. Adam Godzik earned his Ph.D. in physics from the Department of Physics, University of Warsaw, Poland in 1990.
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Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham RT, Schoenberger SP, Mustelin T
Nat Immunol. 2003 Jan;4(1):44-8
Sequence clustering strategies improve remote homology recognitions while reducing search times.
Li W, Jaroszewski L, Godzik A
Protein Eng. 2002 Aug;15(8):643-9
Discovering new genes with advanced homology detection.
Li W, Godzik A
Trends Biotechnol. 2002 Aug;20(8):315-6
In search for more accurate alignments in the twilight zone.
Jaroszewski L, Li W, Godzik A
Protein Sci. 2002 Jul;11(7):1702-13
A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.
Kridel SJ, Sawai H, Ratnikov BI, Chen EI, Li W, Godzik A, Strongin AY, Smith JW
J Biol Chem. 2002 Jun 28;277(26):23788-93
Tolerating some redundancy significantly speeds up clustering of large protein databases.
Li W, Jaroszewski L, Godzik A
Bioinformatics. 2002 Jan;18(1):77-82
CADD, a Chlamydia protein that interacts with death receptors.
Stenner-Liewen F, Liewen H, Zapata JM, Pawlowski K, Godzik A, Reed JC
J Biol Chem. 2002 Mar 22;277(12):9633-6
Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR).
Alonso A, Merlo JJ, Na S, Kholod N, Jaroszewski L, Kharitonenkov A, Williams S, Godzik A, Posada JD, Mustelin T
J Biol Chem. 2002 Feb 15;277(7):5524-8
Identification and characterization of DEDD2, a death effector domain-containing protein.
Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC
J Biol Chem. 2002 Mar 1;277(9):7501-8
A unique substrate recognition profile for matrix metalloproteinase-2.
Chen EI, Kridel SJ, Howard EW, Li W, Godzik A, Smith JW
J Biol Chem. 2002 Feb 8;277(6):4485-91
Adam Godzik's Research Focus
Protein Structure and Function Prediction
Our research is focused on proteins, their sequences, structures and functions, and the relationships between the three. We try to combine insights from physics and biology to answer basic questions about these relations and to use these insights to predict protein structures and functions for uncharacterized proteins from their amino acid sequence.
From physics we know that proteins fold to structures minimizing their free energy. From biology we know that proteins come in families and that many similarities in structure and function are conserved across protein families. Combination of these two points of view helps us understand how changes in protein sequences influence their structures and functions. It also leads to the development of tools for predicting protein structure and function from amino acid sequence.
About Adam Godzik
Dr. Adam Godzik earned his Ph.D. in physics from the Department of Physics, University of Warsaw, Poland in 1990. After postdoctoral work in the European Molecular Biology Laboratory in Heidelberg and The Scripps Research Institute in San Diego, he became an Assistant Professor at The Scripps Research Institute. In 1999 he joined Sanford-Burnham Medical Research Institute as an Associate Professor.