Cancer is caused by changes in our DNA sequences or how those sequences are expressed. These changes can be caused by genetic mutations or by epigenetic alterations (changes that do not alter the genome but affect its function). Understanding how genetic and epigenetic changes arise, the significance of the specific changes and the consequences of inappropriate gene regulation (when genes are turned on or off) can reveal new strategies for drug discovery.
The goal of the Tumor Development program is to dissect the origin and consequences of cancer-specific mutations and epimutations and identify the molecular mechanisms that regulate expression of genes during normal development and cancer.
Advances in Tumor Development
When Genes Lose Their “Spell Check” (Perucho laboratory)
Research - Cancer - Your Health: Genes and Cancer Tumor Development
A Vitamin-Derived Drug (Dawson and Zhang laboratories)