Communications Breakdown: Signal Transduction

Food is a wonderful thing, but imagine if your stomach lost the ability to feel full. You might eat continuously, regardless of the consequences. Fortunately, your body signals you that your stomach is full and you have eaten enough. Now, think about that on the cellular level. Our cells are constantly receiving signals to grow, divide and perform many other functions. But when these signals get crossed, cells can no longer perform the jobs they’ve been assigned. In cancer, cells may ignore the instructions they’re receiving or accept entirely new instructions—to divide recklessly or migrate to another part of the body. If we can learn how these complex signals work, we can find ways to correct them when they go wrong.

Signal transduction research seeks to illuminate the mechanisms cells use to interpret, integrate and act upon the information they receive from other cells. These signals can control gene activity and modify cell behaviors.

Signaling errors can lead to cancer, autoimmune disorders and other major diseases. Sanford-Burnham’s work is part of a massive scientific effort to identify and interpret how signaling proteins govern cells, tissues and organs. This research could lead to many new treatments as we learn how to restore the normal signaling so critical to human health.

Discoveries in Signal Transduction

Designing Targeted Cancer Therapies from the Ground Up (Ronai laboratory)
Good Communication Makes Good Neighbors (Pasquale laboratory)
Retasking Rapamycin

Research - Cancer - Your Health: Communications Breakdown Signal Transduction
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Genes and Cancer: Tumor Development
Communications Breakdown: Signal Transduction
Rebuilding Cancer’s Neighborhood: Tumor Microenvironment
Unlocking the Secrets of Cell Death: Apoptosis and Cell Death Research
Breast Cancer