Immunity and Pathogenesis

Carl Ware & secrets of the immune system

Carl Ware & secrets of the immune system

Dr. Ware’s research focuses on the fundamental pathways that control cytokines, a family of proteins involved in immune signaling.

New insight into mechanisms behind autoimmune diseases suggests a potential therapy

New insight into mechanisms behind autoimmune diseases suggests a potential therapy

Sanford-Burnham researchers have found a potential new therapy for autoimmune diseases—a chemical compound that appears to inhibit a mutant form of the protein LYP.

Study raises questions about lymphoma drugs

Study raises questions about lymphoma drugs

A study led by Robert Rickert, Ph.D. explored the roles of two enzymes, SHIP and PTEN, in B cell growth and proliferation. The results could impact several anti-lymphoma therapies currently in development.

What is immunity and pathogenesis?

Cells of the immune system recognize and eradicate pathogenic organisms and derived toxins. Immunity is provided by cells of the innate (particularly myeloid cell subsets) and adaptive (B and T lymphocytes and NK cells) arms of the immune system. Pathogens evolve mechanisms to evade immunity to establish infections. Excessive or misdirected immune responses can result in chronic inflammation, autoimmunity and degenerative disease.

What is the focus of our program—What questions are
we asking?

The Program is broadly defined by the focus on cellular and molecular mechanisms of the host immune system, versus the mechanisms that viruses and other pathogens employ to evade immune recognition. Current efforts include approaches to characterize host microenvironments and signaling pathways impacted by viral pathogens; neuroinflammation; mucosal immunology and the microbiota; immune regulation by members of the TNF superfamily; functional discrimination of CD4+ T cell subsets and understanding the molecular determinants of B cell differentiation.

How will our research help patients?

Our research is of direct relevance to the design of anti-viral compounds and vaccines. Findings from animal models and human cells also provide insight into the etiology and treatment of chronic inflammatory, autoimmune and infectious diseases. In cancer treatment, the use of biologics to selectively modulate immune cell function is an area that continues to show promise in the clinic. A better understanding of the functional complexities of the immune system can also be applied to improve the diagnosis, stratification and treatment of disease as it pertains to the individual and personalized medicine.


Recent Developments

donation

Re-thinking drug strategies for lupus

Sanford-Burnham researchers have completed a study that shows how treating lupus and other autoimmune diseases may require a broader approach than previously thought. The study, recently published in the journal Cell Reports, implicates a signaling pathway called “PI3K,” that is essential for B cell survival.  Read More...

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