What is the focus of our program—What questions are
Thematic strengths within the Diabetes and Obesity Research Center CPP surround muscle fuel metabolism – i.e., the way the heart and other muscles obtain energy to support their strength and function throughout life. The hormones that control muscle (heart, skeletal, and smooth muscle) health, regeneration, and mitochondrial function also represent important research emphases—with diagnostic potential that can help guide individualized approaches to cardiovascular disease treatment.
How will our research help patients?
Diabetes and obesity impair heart muscle pump function, skeletal muscle strength, and blood flow, thus causing fatigue, weakness, stroke, heart attack, kidney failure, and poor circulation that conveys risk for foot amputation. The goal of the Diabetes and Obesity Research Center’s CPP is to utilize a fundamental understanding of muscle fuel metabolism as a mechanism to discover new molecular targets and therapeutics that preserve or restore cardiovascular health. In this way, we seek to develop personalized strategies that reduce cardiovascular frailty in order to maintain patient mobility, vitality, productivity, and autonomy.