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Stem Cell and Regenerative Biology
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For brain tumors, origins matter
Research by Dr. Robert Wechsler-Reya shows that brain tumors arising from different cell types might require different—and more personalized—treatment approaches.
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Stem cells 101
Learn about stem cells and how they are revolutionizing medical research.
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Transplanted neural stem cells treat ALS in mouse model
A consortium of ALS researchers shows that transplanting neural stem cells into the spinal cord of an ALS mouse model slows disease onset and progression, improves motor function, and significantly prolongs survival.
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Studying stem cells and regenerative biology
Scientists in the Stem Cells and Regenerative Biology Program are working to understand the biology of embryonic stem cells, which give rise to the many different types of cells of the body, and adult stem cells, which reside in many tissues as reservoirs of regeneration and repair. They are also studying how to reprogram adult cells of any tissue type into induced pluripotent stem cells, a specially engineered type of stem cell that have a lot in common with their embryonic cousins.
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Researchers in this program are working to fully understand the role that stem cells play:
- During the earliest stages of development when organs and tissues first form
- During normal physiology (tissue homeostasis)
- When early development goes awry and abnormalities arise
- During the onset of cancer (oncogenesis)
- During degeneration and aging
How our research helps improve health
At the same time researchers are unraveling basic stem cell biology in human development, they are also harnessing stem cell technology to regenerate or replace diseased or damaged tissue. In addition, our scientist are using induced pluripotent stem cells to model diseases in a dish and applying these models to better understand disease and test new treatments.
Research - Neuroscience, Aging and Stem Cell - Stem Cell and
Regenerative Biology: How Our Research Helps |
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More about the program
Evan Snyder, M.D., Ph.D., director of the Stem Cells and Regenerative Biology Program, talks about stem cells as the fundamental makeup of an organism. He and others in the program hope to better understand how these cells help maintain an organism’s well-being throughout life in order to invoke the same principles to combat human diseases. |
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Lifespan Differences in Hematopoietic Stem Cells are Due to Imperfect Repair and Unstable Mean-Reversion.
Sieburg HB, Cattarossi G, Muller-Sieburg CE.
PLoS Comput Biol. 2013 Apr;9(4):e1003006. doi: 10.1371/journal.pcbi.1003006. Epub 2013 Apr 18.
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Deriving dopaminergic neurons for clinical use. A practical approach.
Gonzalez R, Garitaonandia I, Abramihina T, Wambua GK, Ostrowska A, Brock M, Noskov A, Boscolo FS, Craw JS, Laurent LC, Snyder EY, Semechkin RA.
Sci Rep. 2013 Mar 15;3:1463. doi: 10.1038/srep01463.
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Identification of human embryonic progenitor cell targeting peptides using phage display.
Bignone PA, Krupa RA, Sternberg H, Funk WD, Snyder EY, West MD, Larocca D.
PLoS One. 2013;8(3):e58200. doi: 10.1371/journal.pone.0058200. Epub 2013 Mar 4.
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MMP-3 mediates psychosine-induced globoid cell formation: Implications for leukodystrophy pathology.
Ijichi K, Brown GD, Moore CS, Lee JP, Winokur PN, Pagarigan R, Snyder EY, Bongarzone ER, Crocker SJ.
Glia. 2013 May;61(5):765-77. doi: 10.1002/glia.22471. Epub 2013 Feb 13.
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Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis.
Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyankar MB, Marconi M, Li J, Yu D, Han I, Maragakis NJ, Lládo J, Erkmen K, Redmond DE Jr, Sidman RL, Przedborski S, Rothstein JD, Brown RH Jr, Snyder EY.
Sci Transl Med. 2012 Dec 19;4(165):165ra164. doi: 10.1126/scitranslmed.3004579.
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Optical imaging of progenitor cell homing to patient-derived tumors.
Newton IG, Plaisted WC, Messina-Graham S, Abrahamsson Schairer AE, Shih AY, Snyder EY, Jamieson CH, Mattrey RF.
Contrast Media Mol Imaging. 2012 Nov-Dec;7(6):525-36. doi: 10.1002/cmmi.1485.
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Research - Neuroscience, Aging and Stem Cell - Stem Cell and
Regenerative Biology: Recent Publications |
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