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Stem Cell and Regenerative Biology
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A new stem cell enters the mix
Dr. Evan Snyder and his team generated a new type of stem cell that’s easier to produce and shows therapeutic benefit in a rodent stroke model.
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How to make new neurons
Dr. Stuart Lipton and collaborators found a way to reprogram human skin cells directly into functioning neurons—a first step in creating personalized therapies for Alzheimer’s disease and other neurological disorders.
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What is “Disease in a Dish?”
Learn more about this state-of-the-art stem cell technology and how it’s being used to better understand disease and discover new medicines.
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Studying stem cells and regenerative biology
Scientists in the Stem Cells and Regenerative Biology Program are working to understand the biology of embryonic stem cells, which give rise to the many different types of cells of the body, and adult stem cells, which reside in many tissues as reservoirs of regeneration and repair. They are also studying how to reprogram adult cells of any tissue type into induced pluripotent stem cells, a specially engineered type of stem cell that have a lot in common with their embryonic cousins.
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Researchers in this program are working to fully understand the role that stem cells play:
- During the earliest stages of development when organs and tissues first form
- During normal physiology (tissue homeostasis)
- When early development goes awry and abnormalities arise
- During the onset of cancer (oncogenesis)
- During degeneration and aging
How our research helps improve health
At the same time researchers are unraveling basic stem cell biology in human development, they are also harnessing stem cell technology to regenerate or replace diseased or damaged tissue. In addition, our scientist are using induced pluripotent stem cells to model diseases in a dish and applying these models to better understand disease and test new treatments.
Research - Neuroscience, Aging and Stem Cell - Stem Cell and
Regenerative Biology: How Our Research Helps |
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More about the program
Evan Snyder, M.D., Ph.D., director of the Stem Cells and Regenerative Biology Program, talks about stem cells as the fundamental makeup of an organism. He and others in the program hope to better understand how these cells help maintain an organism’s well-being throughout life in order to invoke the same principles to combat human diseases. |
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Predicting clonal self-renewal and extinction of hematopoietic stem cells.
Sieburg HB, Rezner BD, Muller-Sieburg CE.
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4370-5. Epub 2011 Feb 28.
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Self-renewal induced efficiently, safely, and effective therapeutically with one regulatable gene in a human somatic progenitor cell.
Kim KS, Lee HJ, Jeong HS, Li J, Teng YD, Sidman RL, Snyder EY, Kim SU.
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4876-81. Epub 2011 Mar 4.
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Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury.
Obenaus A, Dilmac N, Tone B, Tian HR, Hartman R, Digicaylioglu M, Snyder EY, Ashwal S.
Ann Neurol. 2011 Feb;69(2):282-91. doi: 10.1002/ana.22168. Epub 2010 Nov 22.
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Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions.
Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA, Ding S.
Cell Stem Cell. 2011 Aug 5;9(2):113-8. Epub 2011 Jul 28.
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Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation.
Yang CS, Lopez CG, Rana TM.
Stem Cells. 2011 Oct;29(10):1528-36. doi: 10.1002/stem.717.
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Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors.
Li W, Sun W, Zhang Y, Wei W, Ambasudhan R, Xia P, Talantova M, Lin T, Kim J, Wang X, Kim WR, Lipton SA, Zhang K, Ding S.
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8299-304. Epub 2011 Apr 27.
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Research - Neuroscience, Aging and Stem Cell - Stem Cell and
Regenerative Biology: Recent Publications |
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