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“Junk DNA” drives embryonic development
Dr. Mark Mercola and his team discovered that microRNAs play an important roll in embryonic development.
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Recycling fat to live longer?
Dr. Malene Hansen and her lab are unraveling how the interplay between two cellular processes—autophagy and lipid metabolism—influences lifespan in C. elegans worms.
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Sanford-Burnham research projects selected to go to space
Space Florida to send two experiments from Sanford-Burnham Medical Research Institute to the International Space Station.
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Studying development and aging
The goal of this program is to understand how a functioning organ is formed and maintained in the organism, and how to correct or ameliorate a genetically or environmentally induced defect. To achieve this goal, our program's scientists are investigating the cellular and molecular interactions—from embryo to adult—that control the assembly and physiological operation of organs to ensure an organism’s health.
Research - Neuroscience, Aging and Stem Cell - Development and
Aging: About |
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Researchers in the Development and Aging Program are taking several approaches to understand the molecular basis of embryological development, from a fertilized egg to the establishment of the embryonic axis, to the differentiation and morphogenesis of individual tissues, their homeostasis under different metabolic and environmental conditions, and finally to the process of aging. Many of our projects use model systems, such as C. elegans (worms), Drosophila (fruit flies), and mice, to investigate how the activities of signaling molecules and transcription factors are integrated to control developmental processes.
How our research helps improve health
Understanding fundamental principles in biology during development, organ function, and aging constitutes the basis of all medical advances and represents the backbone of any therapeutic intervention. Current studies are focused on understanding the mechanisms that control the development and physiology of the brain, heart, skeleton, and pancreas. The program's research analyzes invertebrate and vertebrate model systems, as well as primary human tissue, with projects focused on understanding congenital heart disease and cardiac malfunction, skeletal mineralization disorders, cellular complexity in the brain, and pancreatic islet regeneration and regulation of insulin-producing beta-cells in normal versus diabetic states.
Research - Neuroscience, Aging and Stem Cell - Development and
Aging: How Our Research Helps |
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Complex Genetic Architecture of Cardiac Disease in a Wild Type Inbred Strain of Drosophila melanogaster.
Zhang Z, Hsieh B, Poe A, Anderson J, Ocorr K, Gibson G, Bodmer R.
PLoS One. 2013 Apr 29;8(4):e62909. doi: 10.1371/journal.pone.0062909. Print 2013.
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Coronary veins determine the pattern of sympathetic innervation in the developing heart.
Nam J, Onitsuka I, Hatch J, Uchida Y, Ray S, Huang S, Li W, Zang H, Ruiz-Lozano P, Mukouyama YS.
Development. 2013 Apr;140(7):1475-85. doi: 10.1242/dev.087601. Epub 2013 Mar 5.
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A cool way to live long.
Conti B, Hansen M.
Cell. 2013 Feb 14;152(4):671-2. doi: 10.1016/j.cell.2013.01.050.
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Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.
Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, Kan NG, Forcales S, Puri PL, Leone TC, Marine JE, Calkins H, Kelly DP, Judge DP, Chen HS.
Nature. 2013 Feb 7;494(7435):105-10. doi: 10.1038/nature11799. Epub 2013 Jan 27.
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A Drosophila model of high sugar diet-induced cardiomyopathy.
Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R.
PLoS Genet. 2013 Jan;9(1):e1003175. doi: 10.1371/journal.pgen.1003175. Epub 2013 Jan 10.
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Autophagy genes are required for normal lipid levels in C. elegans.
Lapierre LR, Silvestrini MJ, Nuñez L, Ames K, Wong S, Le TT, Hansen M, Meléndez A.
Autophagy. 2013 Mar;9(3):278-86. doi: 10.4161/auto.22930. Epub 2013 Jan 15.
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Research - Neuroscience, Aging and Stem Cell - Development and
Aging: Recent Publications |
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