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How to make new neurons
Dr. Stuart Lipton and collaborators found a way to reprogram human skin cells directly into functioning neurons—a first step in creating personalized therapies for Alzheimer’s disease and other neurological disorders.
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Meet Dr. Randal Kaufman
Dr. Kaufman joined Sanford-Burnham’s faculty in July 2011, where he now leads the Degenerative Disease Research Program.
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Serendipity in science
Dr. Dongxian Zhang and his lab are making new discoveries in motor neuron degeneration—the cause of lethal diseases such as spinal muscular atrophy and Lou Gehrig’s disease.
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Studying degenerative disease
The Degenerative Disease Research Program seeks to understand the fundamental molecular changes responsible for cell and tissue degeneration in the nervous system and other organs. Researchers in this program study degenerative diseases such as stroke, Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease, Huntington's disease, HIV-associated dementia, diabetes, and glaucoma.
Research - Neuroscience, Aging and Stem Cell - Degenerative
Disease: About |
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Our degenerative disease researchers are a highly collaborative, multidisciplinary group with combined expertise in neurotransmitter receptor/ion-channel electrophysiology, mouse models of stroke and neurodegeneration, nitrosyl-free radical chemistry, and signal transduction research.
How our research helps improve health
Discoveries made by scientists in this program have paved the way for development of a drug for Alzheimer's disease that, for the first time, gets to the root of the problem, possibly preventing brain cell death rather than merely masking symptoms caused by loss of these cells. A number of other strategies are now being developed for either protecting cells or replacing cells lost due to degenerative diseases of the brain and other organs.
Research - Neuroscience, Aging and Stem Cell - Degenerative
Disease: How Our Research Helps |
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Research - Neuroscience, Aging and Stem Cell - Degenerative Disease:
Recent Developments
Recent Developments
Your support is crucial in turning hope into healing. Learn More
Using stem cells to treat Parkinson’s disease
A team led by Dr. Stuart Lipton discovers how stem cells can be used to generate dopamine-producing neurons and how these cells show therapeutic benefit in a rodent model of Parkinson’s disease.
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S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.
Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, Lipton SA.
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14330-5. Epub 2011 Aug 15.
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MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.
Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton SA.
PLoS One. 2011;6(8):e24027. Epub 2011 Aug 25.
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Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.
Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR 3rd, Lipton SA.
Mol Cell. 2010 Jul 30;39(2):184-95.
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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.
Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA.
Nat Med. 2009 Dec;15(12):1407-13. Epub 2009 Nov 15.
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Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model.
Wang R, Yang B, Zhang D.
Glia. 2011 Jun;59(6):946-58. doi: 10.1002/glia.21167. Epub 2011 Mar 28.
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Proteolytic processing of Alzheimer's β-amyloid precursor protein.
Zhang H, Ma Q, Zhang YW, Xu H.
J Neurochem. 2011 Nov 28. doi: 10.1111/j.1471-4159.2011.07519.x. [Epub ahead of print]
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Research - Neuroscience, Aging and Stem Cell - Degenerative
Disease: Recent Publications |
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