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Carl Ware & secrets of the immune system
Dr. Ware’s research focuses on the fundamental pathways that control cytokines, a family of proteins involved in immune signaling.
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Salvatore Albani & the Zen of translational medicine
Taking a “bench-to-bedside” approach to research, Dr. Albani is developing a new drug designed to treat rheumatoid arthritis.
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What causes neurological damage in HIV?
Dr. Marcus Kaul’s research reveals that microglia, immune cells found in the brain, flood the brain with toxic factors in response to HIV.
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Studying inflammatory diseases
Researchers in the Inflammatory Disease Research Program are studying the central players in human inflammatory disease processes, the innate and adaptive immune systems, and the molecular mechanisms of diseases such as rheumatoid arthritis. Insights from these studies are used for the rational, structure-based design of new therapeutics. In addition to traditional cellular biochemistry and molecular biology, the program emphasizes study of human tissue samples and DNA, genetics, proteomics, bioinformatics, new imaging techniques, electron microscopy, structural biology, rational drug design, chemistry, protein engineering, and nanotechnology.
Research - Infectious and Inflammatory Disease - Inflammatory
Disease: About |
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Inflammation is the body’s basic response to a variety of external or internal insults, such as infectious agents, physical injury, hypoxia, or disease processes in nearly any organ or tissue in the body. Inflammation entails the four well-known symptoms—redness, heat, tenderness/pain and swelling—that characterize so many common diseases and conditions.
How our research helps improve health
Chronic inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes, affect more than 50 million Americans. Many of these diseases are debilitating and are becoming increasingly common in our aging society.
In Sanford-Burnham’s Inflammatory Disease Research Program, researchers have had significant success in identifying a gene variant associated with type 1 diabetes. This finding has now been expanded into rheumatoid arthritis and systemic lupus erythematosus. Other contributions include discoveries about specific genes and enzymes related to human disease, including infectious with the bacterium that causes anthrax.
Research - Infectious and Inflammatory Disease - Inflammatory
Disease: How Our Research Helps |
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Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease.
Rickert RC, Jellusova J, Miletic AV.
Immunol Rev. 2011 Nov;244(1):115-33. doi: 10.1111/j.1600-065X.2011.01067.x.
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Magnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysis.
Cato MH, Yau IW, Rickert RC.
Nat Protoc. 2011 Jun 9;6(7):953-60. doi: 10.1038/nprot.2011.344.
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IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization.
Li CR, Deiro MF, Godebu E, Bradley LM.
J Autoimmun. 2011 Jul 9. [Epub ahead of print]
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Multifaceted regulation of T cells by CD44.
Baaten BJ, Li CR, Bradley LM.
Commun Integr Biol. 2010 Nov;3(6):508-12. Epub 2010 Nov 1.
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Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.
Sato-Hashimoto M, Saito Y, Ohnishi H, Iwamura H, Kanazawa Y, Kaneko T, Kusakari S, Kotani T, Mori M, Murata Y, Okazawa H, Ware CF, Oldenborg PA, Nojima Y, Matozaki T.
J Immunol. 2011 Jul 1;187(1):291-7. Epub 2011 Jun 1.
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The TNF receptor super family in immune regulation.
Ware CF.
Immunol Rev. 2011 Nov;244(1):5-8. doi: 10.1111/j.1600-065X.2011.01065.x.
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View All Publications
Research - Infectious and Inflammatory Disease - Inflammatory
Disease: Recent Publications |
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