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10 Years of science and counterterrorism
Dr. Robert Liddington solved the crystal structure of the anthrax lethal factor. Later, he and several colleagues discovered chemical inhibitors that neutralize the anthrax lethal factor, making a significant advance toward a treatment.
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Assembling to attack infection
Using x-ray crystallography, researchers solved the 3D crystal structure of C6, the immune system’s complement membrane attack complex.
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Studying infectious diseases
Researchers in the Infectious Diseases Program seek to better understand the molecular mechanisms of disease. One area of research focuses on structure-function correlates of virulence factors and essential genes from bacteria and viruses, including the processing proteases of the flaviviruses (e.g. West Nile and Dengue virus) and variola virus, the causative agent of smallpox. Building on this infrastructure, the program is also studying emerging diseases including potential pandemic viruses. Achievements by researchers in this program have included a significant advance toward an emergency treatment for anthrax.
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The need to understand and develop treatments for infectious diseases is great. It is currently estimated that within the next 10 years many antibiotics currently employed for treating bacterial infections will no longer be effective due to microbial resistance. Drug-resistant strains of some pathogens, such as the bacteria that cause tuberculosis, have already appeared. In addition, very few treatments for viral infections exist to date. Moreover, several deadly viral agents are on the rise.
How our research helps improve health
With continued exploration of how viral and bacterial infections attack the body and spread, researchers can develop vaccines and treatments for diseases. These could be crucial when the next pandemic illness strikes, and can improve the quality of life for those living will illnesses such as HIV.
Research - Infectious and Inflammatory Disease - Infectious
Disease: How Our Research Helps |
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Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.
Gerlic M, Faustin B, Postigo A, Yu EC, Proell M, Gombosuren N, Krajewska M, Flynn R, Croft M, Way M, Satterthwait A, Liddington RC, Salek-Ardakani S, Matsuzawa S, Reed JC.
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7808-13. doi: 10.1073/pnas.1215995110. Epub 2013 Apr 19.
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Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells.
Lu S, Wang Y, Huang H, Pan Y, Chaney EJ, Boppart SA, Ozer H, Strongin AY, Wang Y.
PLoS One. 2013;8(3):e58569. doi: 10.1371/journal.pone.0058569. Epub 2013 Mar 13.
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Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.
PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.
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Targeting the T-cell membrane type-1 matrix metalloproteinase-CD44 axis in a transferred type 1 diabetes model in NOD mice.
Savinov AY, Strongin AY.
Exp Ther Med. 2013 Feb;5(2):438-442. Epub 2012 Nov 20.
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HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.
Wu B, Zhang Z, Noberini R, Barile E, Giulianotti M, Pinilla C, Houghten RA, Pasquale EB, Pellecchia M.
Chem Biol. 2013 Jan 24;20(1):19-33. doi: 10.1016/j.chembiol.2012.10.015.
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High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.
Shiryaev SA, Chernov AV, Golubkov VS, Thomsen ER, Chudin E, Chee MS, Kozlov IA, Strongin AY, Cieplak P.
PLoS One. 2013;8(1):e54290. doi: 10.1371/journal.pone.0054290. Epub 2013 Jan 15.
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View All Publications
Research - Infectious and Inflammatory Disease - Infectious
Disease: Recent Publications |
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