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Metabolic Signaling and Disease
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How cells absorb blood glucose
Dr. Zhen Jiang's laboratory has identify a new protein that's involved glucose uptake, an important step in the development of diabetes.
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Mitochondria...start your engines please
Dr. Sheila Collins' laboratory identified a molecule in brown body fat called the uncoupling protein which “leaks” energy. Learning how to activate brown fat may provide a new therapeutic target for treating obesity.
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Taste receptors...in the gut?
Dr. Tim Osborne's laboratory is investigating bitter taste-sensing receptors in the gut that act as a second line of defense to keep toxins from being absorbed by the digestive system.
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Studying metabolic signaling and disease
Researchers in the Metabolic Signaling and Disease Program study how organs and cells work together to respond to biological and environmental challenges that lead to the development of metabolic diseases such as diabetes and obesity. The program brings together investigators with complementary expertise in cell and molecular biology, chemistry, and physiology to understand mechanisms that regulate metabolic flow, energy expenditure, and appetite control. Since metabolic changes are also fundamental to many other pathological conditions, ranging from Alzheimer's disease to cancer, the basic principles of our research will also provide insight and therapeutic avenues for combating other human diseases.
Research - Diabetes and Obesity - Metabolic Signaling: About |
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The program focuses on the integration of the extrinsic and intrinsic cell signaling networks with gene regulatory mechanisms involved in energy generation and storage pathways. Multi-disciplinary teams use an integrated multi-organ and multi-system approach to study the biologic and physiologic mechanisms of metabolic disease. This approach is essential to understanding how different organ systems communicate together to provide metabolic balance for the entire body.
How our research helps improve health
When the metabolic system is out of balance due to genetic, environmental, or dietary factors, diseases such as obesity and diabetes develop. An estimated 60 percent of the U.S. adult population is overweight or obese. By understanding the molecular regulatory mechanisms that maintain metabolic homeostasis, our scientists can identify new drug targets that will be exploited for novel therapies to reverse the extreme rise in the incidence of type 2 diabetes that has occurred over the past several decades.
Research - Diabetes and Obesity - Metabolic Signaling: How Our
Research Helps |
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The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.
Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP.
Genes Dev. 2011 Dec 1. [Epub ahead of print]
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C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.
Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY.
Cell Metab. 2011 Sep 7;14(3):378-89.
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Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein -1a.
Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF.
Cell Metab. 2011 May 4;13(5):540-9.
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Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.
Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR.
Nature. 2011 Apr 28;472(7344):486-90. Epub 2011 Mar 27.
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Multicenter, placebo-controlled trial of lorcaserin for weight management.
Smith SR, Weissman NJ, Anderson CM, Sanchez M, Chuang E, Stubbe S, Bays H, Shanahan WR; Behavioral Modification and Lorcaserin for Overweight and Obesity Management (BLOOM) Study Group.
N Engl J Med. 2010 Jul 15;363(3):245-56.
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Acute stimulation of white adipocyte respiration by PKA-induced lipolysis.
Yehuda-Shnaidman E, Buehrer B, Pi J, Kumar N, Collins S.
Diabetes. 2010 Oct;59(10):2474-83. Epub 2010 Aug 3.
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Research - Diabetes and Obesity - MetabolicSignaling: Recent
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