Diabetes and Obesity Research Center

Building translational research

Building translational research

The Translational Research Institute for Metabolism and Diabetes provides a bridge between laboratory and patient-oriented research.

Fighting Fat

Fighting Fat

Sanford-Burnham researchers discovered that orexin, a hormone produced in the brain, activates calorie-burning brown fat in mice.

New partnership to study obesity

New partnership to study obesity

Sanford-Burnham's collaboration with Takeda Pharmaceutical and Florida Hospital aims to discover new therapeutic approaches to treat obesity.

About the Diabetes and Obesity Center

Our scientists seek to explore the metabolic basis of disease and to rapidly translate discovery to clinical care by leveraging the bridges we have built with clinical partners.

- Daniel Kelly, M.D.

Scientific Director, Sanford-Burnham at Lake Nona

Type 2 diabetes, which is driven by obesity, has increased nearly 30 percent in the last decade, with more than 60 percent of U.S. adults diagnosed as overweight or obese. To address these challenges, scientists in the Diabetes and Obesity Research Center are studying the metabolic basis of obesity-related diabetes and its cardiovascular complications. The center is focused on translational research and has established advanced technology resources and formed clinical and pharmaceutical research partnerships to drive their discoveries toward patient application.

Read on to learn more about our scientific programs, drug discovery capabilities, and shared resources, or visit our blog for frequent updates.

Learn more about our diabetes and obesity research in the following fields:

Research - Diabetes and Obesity: About

Recent Developments

Diabetes and Obesity Research Programs

The Diabetes and Obesity Research Center uses a multi-disciplinary approach to study the complex interactions of common metabolic diseases and corresponding cardiovascular complications. Scientists are interested in fundamental questions about disease: What happens when the brain-body “crosstalk” fails? How does a person’s genetic background and metabolic make-up dictate the development of obesity and the onset and severity of diabetes? How do errors in fuel burning contribute to the development of metabolic disease? Why is heart disease more difficult to treat in diabetics than heart disease in non-diabetics?

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