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Muscle Development and Regeneration
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A few minutes with Dr. Mark Mercola
Dr. Mark Mercola directs Sanford-Burnham’s Muscle Development and Regeneration Program and is looking for ways to regenerate damaged heart tissue.
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Putting the muscle in muscle stem cells
Dr. Pier Lorenzo Puri and colleagues are figuring out ways to keep the muscle stem cell pool fresh and ready to regenerate injured or diseased muscle—a therapeutic approach that might one day benefit patients with muscular dystrophy.
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Studying muscle development and regeneration
The Muscle Development and Regeneration Program focuses on understanding the cause of and developing therapies for heart and skeletal muscle disorders with emphasis on three areas of research: 1) the molecular basis of congenital heart disease, 2) strategies for regeneration of heart and skeletal muscle cells for treatment of degenerative diseases, and 3) developmental basis and pathogenesis of myopathies, including muscle cell structural anomalies and pathological myocardial hypertrophy.
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This program builds on current strengths in mouse transgenic and surgical models of heart disease, including congenital heart disease, research on muscle stem and progenitor cells, and discovery of small molecule and microRNA regulators of muscle development that will be used to develop probes of muscle disease and drugs for therapy. The program’s focus complements the interests of the Cardiovascular Pathobiology Program, which emphasizes adult heart disease, the Development and Aging Program, which focuses on basic developmental biology and aging mechanisms, the Stem Cell and Regeneration Program, which focuses on broad issues of stem cell potency, differentiation and applications in regenerative medicine, and the RNA Biology Program, which is working to understand how the world of non-coding RNAs guides cellular processes in health and disease.
How our research helps improve health
Heart and skeletal muscle disorders contribute to substantial mortality and morbidity not only for adults but also for children and young adults. Researchers in the Muscle Development and Regeneration Program are developing therapies for these diseases.
Research - Children's Health - Muscle Development and Regeneration:
How Our Research Helps |
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Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex.
Forcales SV, Albini S, Giordani L, Malecova B, Cignolo L, Chernov A, Coutinho P, Saccone V, Consalvi S, Williams R, Wang K, Wu Z, Baranovskaya S, Miller A, Dilworth FJ, Puri PL.
EMBO J. 2011 Nov 8. doi: 10.1038/emboj.2011.391. [Epub ahead of print]
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Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia.
Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA.
Mol Cell. 2011 Nov 18;44(4):532-44.
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Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm.
Willems E, Spiering S, Davidovics H, Lanier M, Xia Z, Dawson M, Cashman J, Mercola M.
Circ Res. 2011 Aug 5;109(4):360-4. Epub 2011 Jul 7.
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Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice.
Sacco A, Mourkioti F, Tran R, Choi J, Llewellyn M, Kraft P, Shkreli M, Delp S, Pomerantz JH, Artandi SE, Blau HM.
Cell. 2010 Dec 23;143(7):1059-71. Epub 2010 Dec 9.
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TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.
Palacios D, Mozzetta C, Consalvi S, Caretti G, Saccone V, Proserpio V, Marquez VE, Valente S, Mai A, Forcales SV, Sartorelli V, Puri PL.
Cell Stem Cell. 2010 Oct 8;7(4):455-69.
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Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
Kim C, Majdi M, Xia P, Wei KA, Talantova M, Spiering S, Nelson B, Mercola M, Chen HS.
Stem Cells Dev. 2010 Jun;19(6):783-95.
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Research - Children's Health - Muscle Development and Regeneration:
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