Neuroscience and Aging Research Center

Sanford-Burnham and Intrexon Corp. establish collaboration to accelerate stem cell research

Sanford-Burnham and Intrexon Corp. establish collaboration to accelerate stem cell research

New collaboration combines Sanford-Burnham’s renowned scientific team and Intrexon’s proprietary discovery platforms to accelerate human iPSC research.

Sanford-Burnham research projects selected to go to space

Sanford-Burnham research projects selected to go to space

Space Florida to send two experiments from Sanford-Burnham Medical Research Institute to the International Space Station.

Searching for causes of neuron death in Alzheimer’s and TBI

Searching for causes of neuron death in Alzheimer’s and TBI

Sanford-Burnham researchers discovered that the protein appoptosin prompts neurons to commit suicide in several neurological conditions.

About the Neuroscience and Aging Research Center


At our center we have two approaches…we want to protect cells in the brain, particularly nerve cells, from a variety of neurodegenerative diseases like Alzheimer’s and Parkinson’s and we’re also trying to regenerate neurons and associated cells.

- Stuart Lipton, M.D., Ph.D.

Professor and Director,
Neuroscience and Aging Research Center

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million. NARC’s mission is to translate discoveries from basic molecular research and apply a systems approach to generate breakthrough therapies for devastating neurologic and cardiac diseases.

What are the goals and activities of the Center?

NARC translates basic science discoveries into new treatments to extend lifespan and to combat degenerative disorders associated with aging or development. Our researchers are discovering the etiological pathways as well as small-molecule and stem cell-based treatments to address the clinical unmet need of these patients.

The Center uses a team based approach to apply our expertise in stem cells to develop therapies for new treatments for stroke and Parkinson’s disease. We are also performing high-throughput screens to identify new molecules to protect the synapses of nerves—the connections between nerves that mediate movement, memory and cognition—for Alzheimer’s, Parkinson’s and autism. By studying the links between Down syndrome and Alzheimer’s disease, we are exploring new treatments to improve cognition in both disorders.

Our collaborations with clinical partners enable us to test new discoveries in human trials, with a goal to improve the lives of patients and families affected by neurodegenerative disease and aging disorders.

Recent Developments

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