2014 Scientific Symposium

Preliminary Program

Keynote Lecture

Larry Goldstein

Human Metabolic Disease: Lessons from the Extremes


Sir Stephen O’Rahilly
University of Cambridge
Tuesday, March 4, 8:00 a. m.

Monday, March 3

7:00 am - Registration and Continental Breakfast

8:15 am - Introductory Remarks




8:30 am - Session 1

Origins of Metabolic Disease


Sabatini.png

Regulation of growth by the mTOR pathway


David M. Sabatini
Whitehead Institute, Massachusetts Institute of Technology


Lee Rubin

A Genome‐wide view of macrophage activation


Christopher K. Glass
University of California San Diego


Lee Rubin

Gene environment interactions in insulin resistance


C. Ronald Kahn
Joslin Diabetes Center


10:00 am - Break



10:30 am - Session 2

Complications of Metabolic Disease


Lee Rubin

Integrating metabolism around the clock


Mitchell A. Lazar
University of Pennsylvania


Lee Rubin

How the HDL receptor SR-BI influences cardiovascular and reproductive pathophysiology


Monty Krieger
Massachusetts Institute of Technology


Lee Rubin

Calcium signaling and ER stress in type 2 diabetes


Ira Tabas
Columbia University


12:00pm - Lunch


1:30 pm - Session 3

Host-Environmental Interactions in Metabolic Disease


Mark Mercola

Crosstalk between circadian and metabolic cycles


Ueli Schibler
University of Geneva


Jenny Hsieh

Clock coupling of protein modification to cell metabolism


Joseph T. Bass
Northwestern University


Jenny Hsieh

A mitochondrial etiology of metabolic and degenerative diseases, cancer, and aging


Douglas C. Wallace
Children’s Hospital of Philadelphia, University of Pennsylvania


Jenny Hsieh

Coupling of the sterol metabolic network to macrophage infection responses


Peter Ghazal
University of Edinburgh Medical School


3:30 pm - Break



4:00 pm - Session 4

Cancer Metabolism

Mark Mercola

Analyzing cancer cell metabolism in vivo


Ralph J. DeBerardinis
University of Texas Southwestern Medical Center


Mark Mercola

Lymphocyte metabolism in inflammatory disease and leukemia


Jeffrey Rathmell
Duke University


Mark Mercola

The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer


Donald P. McDonnell
Duke University

Randal Kaufman

Protein synthesis and folding: Tipping the balance from survival to death


Randall Kaufman
Sanford-Burnham Medical Research Institute

 

6:00 pm - Poster Session presented by Thermo Fisher & Dinner


Tuesday, March 4

7:15 am - Registration and Continental Breakfast


8:00 am - Keynote Lecture

Larry Goldstein

Human Metabolic Disease: Lessons from the Extremes


Sir Stephen O’Rahilly
University of Cambridge




9:00 am - Session 5

Metabolic Biosignatures of Health and Disease: Towards Precision Medicine


Larry Goldstein

Metabolite profiles and the risk of cardiometabolic disease


Robert E. Gerszten
Massachusetts General Hospital, Harvard Medical School


Ricardo Dolmetsch

Metabolite signatures of insulin resistance


Deborah M. Muoio
Duke University


Ludovic Vallier

Transcriptional networks of adipocytes - friends and foes of PPARy


Susanne Mandrup
University of Southern Denmark



10:30 am - Break



11:00 am - Session 6

Modulating Metabolism as a Therapeutic Strategy I: Small Molecule Targets


Larry Goldstein

Seeing form, function, and opportunity in nuclear receptors


Fraydoon Rastinejad
Sanford-Burnham Medical Research Institute


Larry Goldstein

The regulation of hepatic metabolism by insulin


Morris J. Birnbaum
University of Pennsylvania


Larry Goldstein

De novo lipogenesis and metabolic signaling


Clay F. Semenkovich
Washington University in St. Louis


12:30 pm - Lunch and Poster Viewing


1:30 pm - Session 7

Modulating Metabolism as a Therapeutic Strategy II: Biologics


Larry Goldstein

Brown and Beige Fat: Basic Biology and Novel Therapeutics


Bruce M. Spiegelman
Dana-Farber Cancer Institute, Harvard Medical School


Larry Goldstein

Recruitment of BRITE/beige adipocytes in white adipose depots: signaling pathways old and new


Sheila Collins
Sanford-Burnham Medical Research Institute


Larry Goldstein

Gut‐peptide based poly‐pharmacy for the treatment of obesity and
diabetes


Matthias Tschöp
Helmholtz Center Munich, Technical University of Munich


3:00 pm - Final Remarks

3:15 pm - Meeting Concludes.
Optional Activities around the Orlando area.


Wednesday, March 5

Human Metabolic Phenotyping Workshop

Translational Research Institute for Metabolism and Diabetes


Florida Hospital | Orlando, FL


(Separate Registration Required)


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