Sanford Children’s Health Research Center

“Junk DNA” drives embryonic development

“Junk DNA” drives embryonic development

Mark Mercola, Ph.D., and his team discovered that microRNAs play an important role in the allocation of cells into three germ layers—ectoderm, mesoderm, and endoderm—during development that give rise to all tissues and organs in the body.

Exciting clinical trial news for children with inherited bone disease

Exciting clinical trial news for children with inherited bone disease

José Luis Millán, Ph.D., has studied hypophosphatasia, an inherited disease that makes bones fragile, for the past 15 years. In a recent clinical trial, patients were treated with a new enzyme replacement therapy, showing significant improvement.

Rare bone disorder reveals new insights into autism

Rare bone disorder reveals new insights into autism

Researchers at Sanford-Burnham recently used a mouse model to investigate human multiple hereditary exostoses. They foundt symptoms that meet the three defining characteristics of autism: social impairment, language deficits, and repetitive behavior.

About the Sanford Children's Health Research Center

I have the utmost confidence that this collaboration will promote solutions to some of the most troubling health issues that affect children.

- Denny Sanford

Naming donor and Honorary Trustee

Many diseases that predominantly affect children are largely unaddressed by the biopharmaceutical industry and underfunded by government agencies. The mission of the Sanford Center for Children’s Health Research is to make meaningful progress towards combating the diseases of children.

What are the goals and activities of the Center?

Our goal is to be a world leader in providing solutions to childhood diseases. Our approach is to combine outstanding basic research with innovative technologies to translate discoveries into clinical benefits.

We emphasize developmental biology and have core strengths in stem cells and developmental biology to help us to understand what goes wrong in children with inherited diseases and provide us with insights into regeneration and replacement of defective organs and tissues.

We employ a multi-disciplinary strategy to assemble complementary talents and focus them on solving problems in childhood health. Our team includes expertise in genetically tractable model organisms and chemical biology approaches to identifying chemicals that modulate drug targets, thus setting the stage for production of innovative new therapeutics.

Working together, and with our collaborative partners, our mission is to provide breakthroughs in medical research that lead to cures for life threatening diseases of children.

Recent Developments

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