NCI-Designated Cancer Center

Cellular sensor’s 3D structure reveals new clues for combating cancer

Cellular sensor’s 3D structure reveals new clues for combating cancer

Dr. Francesca Marassi and colleagues determined the 3D structure of a complete, unmodified G-protein-coupled receptor in its native environment: embedded in a lipid membrane.

For brain tumors, origins matter

For brain tumors, origins matter

Research by Dr. Robert Wechsler-Reya shows that brain tumors arising from different cell types might require different—and more personalized—treatment approaches.

Sanford-Burnham cancer researcher added to Nobel Prize watch list

Sanford-Burnham cancer researcher added to Nobel Prize watch list

Dr. Erkki Ruoslahti, cancer researcher and distinguished professor at Sanford-Burnham, was named a 2012 Thomson Reuters Citation Laureate, placing him on the organization’s list of “Nobel-class” scientists.

About the Cancer Center

Our goal is an increased translational focus on tailoring new cancer therapies to individual patients, thus enabling personalized medicine.

- Garth Powis, Ph.D.

Professor and Director,
Cancer Center

National Cancer InstituteThe Sanford-Burnham Medical Research Institute (SBMRI) Cancer Center is one of only seven National Cancer Institute (NCI)-designated basic research cancer centers in the country. Its mission is to be a national leader in the effort to overcome cancer as a cause of human suffering and death.

What are the goals and activities of the Center?

Founded in 1976 as the La Jolla Cancer Research Foundation, the Cancer Center first received its NCI-designation in 1981. Cancer Center goals are to conduct paradigm-shifting, collaborative multidisciplinary basic research into the causes, prevention, and treatment of cancer, leading to new therapies that benefit cancer patients everywhere. We also educate and train the next generation of cancer scientists.

An area of long-standing and exceptional strength of the Cancer Center is basic science discovery into novel cancer gene targets and their mechanisms. Investigators have advanced their discoveries through small-molecule-based drug discovery, an area where we have significant capabilities, into early preclinical therapeutic development. Situated in San Diego, the fifth most populous county and the second largest biotech and life science cluster in the Unites States, Sanford-Burnham's Cancer Center is poised to achieve its vision by leveraging its scientific strengths through collaborations with academic and private sector investigators locally, nationally, and internationally.

Cancer Research Programs

Scientists in each of the Sanford-Burnham Cancer Center's three programs are interested in the most fundamental questions about cancer: How do tumors arise from normal cells? What happens to cellular communication as cancer develops? How do cancer cells interact with their neighboring tissues? How do cancer cells avoid cell death? Explore each program below to learn more about Sanford-Burnham's approach to cancer.

Shared Resources

Technology supporting the three programs

There are many Cancer Center Shared Resources, some of which consist of multiple specialized facilities. Equipped with advanced technology and staffed by technical experts in each field, these core facilities provide powerful support for the research of Cancer Center investigators. These Shared Resources, complemented by several additional Institute cores, are accessible to all Sanford-Burnham investigators.


Collaboration with San Diego Cancer Centers

San Diego National Cancer Institute Cancer Centers Council (C3)


C3 San Diego’s three National Cancer Institute (NCI)-designated Cancer Centers—Sanford-Burnham, UC San Diego Moores Cancer Center, and the Salk Institute—are part of a collaboration known as the San Diego National Cancer Institute Cancer Centers Council (C3). This council was formed to facilitate scientific and academic interactions—clinical, translational (from the lab to the clinic), basic-science, and educational—and to leverage each Cancer Center’s distinct strengths, resources, and talents. C3 aims to speed scientific discovery and translation of innovative treatments for cancer patients in San Diego and beyond.




Recent Developments

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About the Cancer Center
Shared NCI Cancer Centers Council (C3) cores at nearby Centers
Cancer Metabolism, Autophagy, & Nutrient Sensing Symposium
Cell Death and Survival Networks
Progress on the Path to Cancer Cures
Tumor Initiation and Maintenance
Tumor Microenvironment and Metastasis
Cancer Center Postdoc/Grad Student Retreat - July 18, 2013
Cancer Center Shared Resources
Sanford-Burnham Cancer Metabolism Symposium
Chemical Biology and Drug Discovery