|
|
|
|
true
10000
-
Flash mob against cancer
Dr. Erkki Ruoslahti and collaborators may have found a way to attract treatment-laden nanoparticles to tumors.
-
Fueling cancer cell growth
Drs. Jorge Moscat and Maria Diaz-Meco have been working together for more than 20 years to understand the mechanisms influence cellular metabolism—a process that breaks down in cancer.
-
Shrinking tumors with homing peptide
Drs. Michiko and Minoru Fukuda find that coupling a tumor-homing peptide and an anti-cancer drug drastically reduces tumors in a mouse model of colon cancer, with no apparent side effects.
|
|
Studying tumor microenvironment
Growth and spread of cancer involves not just the tumor cells themselves, but also other cells, tissues, and molecules in the environment surrounding the tumor. Research in this program aims to understand the molecular basis of cell-to-cell interaction, cell adhesion and cell migration, how these processes are controlled in normal physiology, how this control is subverted in disease, and how to restore normal control with chemical or biological inhibitors.
|
|
Researchers in this program take advantage of the Institute’s high-throughput screening and analysis facility in the
Conrad Prebys Center for Chemical Genomics to identify chemical compounds that inhibit the cellular processes that allow cancer cells to proliferate. While much of our research is focused on cancer, these studies also have clear relevance to a number of other diseases, especially inflammatory and nervous system disorders.
The program is also home to Sanford-Burnham’s
Vascular Mapping Center—where phage display technology is used to identify peptides that home to individual tumors. An additional strength of the program is its strong expertise in glycosylation, a cellular process fundamental to many different diseases.
How our research helps improve health
Research in this program, combined with that of the other programs in the NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, holds potential for the discovery of new cancer drugs and more safe and effective ways to deliver those drugs to the affected areas while minimizing side effects.
Research - Cancer - Tumor Microenvironment: How Our Research Helps |
|
|
-
Redox signaling at invasive microdomains in cancer cells.
Díaz B, Courtneidge SA.
Free Radic Biol Med. 2011 Sep 29. [Epub ahead of print]
Read More
-
A Src-Tks5 pathway is required for neural crest cell migration during embryonic development.
Murphy DA, Diaz B, Bromann PA, Tsai JH, Kawakami Y, Maurer J, Stewart RA, Izpisúa-Belmonte JC, Courtneidge SA.
PLoS One. 2011;6(7):e22499. Epub 2011 Jul 25.
Read More
-
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT.
Mol Cell. 2011 Oct 7;44(1):134-46.
Read More
-
T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion.
Tyrberg B, Miles P, Azizian KT, Denzel MS, Nieves ML, Monosov EZ, Levine F, Ranscht B.
Islets. 2011 Nov 1;3(6):327-37. Epub 2011 Nov 1.
Read More
-
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
González-López M, Welsh K, Finlay D, Ardecky RJ, Ganji SR, Su Y, Yuan H, Teriete P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND.
Bioorg Med Chem Lett. 2011 Jul 15;21(14):4332-6. Epub 2011 May 24.
Read More
-
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma.
Agemy L, Friedmann-Morvinski D, Kotamraju VR, Roth L, Sugahara KN, Girard OM, Mattrey RF, Verma IM, Ruoslahti E.
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17450-5. Epub 2011 Oct 3.
Read More
View All Publications
Research - Cancer - Tumor Microenvironment: Recent Publications |
|
Global - Left Nav: Bottom Blue Border
|
|
|
|
|
|