Polypharmacology in kinase drug discovery
Dr. Shokat is a pioneer in the development of chemical methods for investigating cellular signal transduction pathways—with a particular focus on protein kinases and lipid kinases.
- Investigator, Howard Hughes Medical Institute
- Professor and Vice Chair
Cellular and Molecular Pharmacology
University of California, San Francisco
- Professor, Chemistry
University of California, Berkeley
Tumor heterogeneity and therapy response
Meenhard Herlyn’s laboratory at The Wistar Institute focuses on the biology that underlies melanoma, the most aggressive form of skin cancer. His efforts have pioneered the use of the three-dimensional “artificial skin” tumor cultures to study the behavior of both tumors and the other cells that sustain tumor growth, a system known as the tumor microenvironment. The Herlyn laboratory has transformed the scientific understanding of stem cells as they relate to cancer, and their work on the networks of signaling pathways in melanoma has formed the basis of numerous therapies now in development or currently under clinical trial.
- Caspar Wistar Professor in Melanoma Research
- Director, The Wistar Institute Melanoma Research Center
- Professor, Molecular and Cellular Oncogenesis Program
The LKB1 tumor suppressor pathway:
decoding metabolic links and
Dr. Shaw studies signal transduction pathways that underlie the development of cancer as well as type 2 diabetes.
- Associate Professor
Molecular and Cell Biology Laboratory
- Howard Hughes Medical Institute Early Career Scientist