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New therapeutic target for heart disease
Dr. Ze'ev Ronai and colleagues show that reducing a protein called Siah2 in mice improves mitochondrial response to low oxygen, a condition cells experience when blood flow is restricted during a heart attack.
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Sanford-Burnham leads International Proteolysis Society meeting
The event, organized by Dr. Guy Salvesen and others, brought together more than 300 researchers from a wide variety of fields to provide educational, training, and networking opportunities at all levels.
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Sending medicine where it’s needed most
A collaboration between Sanford-Burnham research Dr. Maurizio Pellecchia and Dr. Elena Pasquale uses peptides (pieces of protein) to guide medicines directly to tumors.
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Studying signal transduction
Signal transduction research concerns the mechanisms cells use to interpret, integrate, and act upon information received by cell surface receptors or by intracellular signals elicited in response to stress or damage. The conversion of this information into biochemical events that trigger specific pathways, control gene activity, and modify cell behavior are among the main topics studied in this program.
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The Signal Transduction Program focuses on research questions related to the control of cell cycle progression, cell proliferation, DNA damage checkpoint function, stress response pathways, and cellular senescence. The emphasis lies on studies of protein phosphorylation/dephosphorylation, ubiquitin and ubiquitin-like proteins, chromatin organization, and transcription factors that play important roles in these processes. The projects employ state-of-the art technologies, including comprehensive proteomic and phosphoproteomic profiling, as well as high-content and high-throughput screening of siRNA and chemical compound libraries.
How our research helps improve health
Many pathologic disorders in humans arise from malfunctioning signal transduction processes in particular cells or tissues. A substantial proportion of modern-day drug discovery efforts is founded on the premise that pharmacologic manipulation of signaling proteins will prove beneficial in the prevention and treatment of major human afflictions, including cancer and neurodegenerative diseases. Discoveries by scientists in this program have resulted in several new therapies currently in clinical testing, including drugs that block signal transduction proteins needed for cancer cell division and survival and cancer gene therapies that reprogram the genome of tumor cells, making them easier to kill with chemotherapy or radiation.
Research - Cancer - Signal Transduction: How Our Research Helps |
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NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
Mace PD, Wallez Y, Dobaczewska MK, Lee JJ, Robinson H, Pasquale EB, Riedl SJ.
Nat Struct Mol Biol. 2011 Nov 13;18(12):1381-7. doi: 10.1038/nsmb.2152.
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Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia.
Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA.
Mol Cell. 2011 Nov 18;44(4):532-44.
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Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.
Chen M, Gutierrez GJ, Ronai ZA.
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9119-24. Epub 2011 May 13.
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Non-apoptotic role of BID in inflammation and innate immunity.
Yeretssian G, Correa RG, Doiron K, Fitzgerald P, Dillon CP, Green DR, Reed JC, Saleh M.
Nature. 2011 Jun 2;474(7349):96-9. Epub 2011 May 8.
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Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.
Yamaji S, Zhang M, Zhang J, Endo Y, Bibikova E, Goff SP, Cang Y.
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22237-42. Epub 2010 Dec 6.
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REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.
Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GG.
EMBO Rep. 2009 Aug;10(8):866-72. Epub 2009 Jun 26.
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Research - Cancer - Signal Transduction: Recent Publications |
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