EDUCATION

Ph.D. Biochemical Engineering and Science (09/2001)
Kyushu Institute of Technology, Fukuoka, Japan
M. S. Biochemical Engineering (01/1997)
Zhejiang University, Hangzhou, China
B. S. Biochemical Engineering (07/1994)
Zhejiang University, Hangzhou, China

Positions

2004—present Postdoctoral Associate, Burnham Institute for Medical Research, USA
2001–2004 Staff Scientist in Institute for Advanced Biosciences, Keio University, Japan

Honors

2006-2008 Postdoctoral Fellowship, California Breast Cancer Research Program
2005 Merck's Scholar Award
2002 Excellent Paper Award, the Society of Biotechnology, Japan
2000-2001 Ministry of Education, Science, Sports, and Culture (Monbusho) Scholarships
for Privately Financed International Students in Japan
1999-2000 Saneyoshi Scholarship for International Students in Japan
1998-1999 Uemura Scholarship for International Students in Japan


Major research interests

  • Metabolic profiling of breast cancer cells: applications in drug discovery
  • Discover missing genes in metabolic pathways in microorganisms: application to chitin utilization pathway in Shewanella.
  • Structure-functional analysis of Bacillus anthracis prophage endolysins, as a potential anti-infective agent.

Selected Publications

  • C. Yang*, A.D. Richardson*, J.W. Smith and A. Osterman (2007, in press). “Comparative metabolomics of breast cancer”, The Pacific Symposium on Biocomputing (PSB). (* equally contributed authors)
  • C. Yang*, D.A. Rodionov*, X. Li, O.N. Laikova, M.S. Gelfand, O.P. Zagnitko, M.F. Romine, A.Y. Obraztsova, K.H. Nealson, A.L. Osterman (2006, in press). Comparative genomics and experimental characterization of N-acetylglucosamine utilization pathway of Shewanella oneidensis. J Biol Chem. (* equally contributed authors)
  • L.Y. Low*, C. Yang*, M. Perego, A. Osterman, R.C. Liddington (2005). Structure and lytic activity of a Bacillus anthracis prophage endolysin. J Biol Chem 280:35433-35439. (* equally contributed authors)
  • Q. Hua, C. Yang, T. Oshima, H. Mori and K. Shimizu (2004). Analysis of gene expression in Escherichia coli in response to changes of growth-limiting nutrient in chemostat cultures. Appl Environ Microbiol 70:2354-2366.
  • Q. Hua*, C. Yang*, T. Baba, H. Mori and K. Shimizu (2003). Responses of the central metabolism in Escherichia coli to phosphoglucose isomerase and glucose-6-phosphate dehydrogenase knockouts. J Bacteriol. 185:7053-7067. (* equally contributed authors)
  • C. Yang, Q. Hua, T. Baba, H. Mori and K. Shimizu (2003). Analysis of Escherichia coli anaplerotic metabolism and its regulation mechanisms from the metabolic responses to alter dilution rates and phosphoenolpyruvate carboxykinase knockout. Biotechnol. Bioeng. 84:129-144.
  • C. Yang, Q. Hua and K. Shimizu (2002). Metabolic flux analysis in Synechocystis using isotope distribution from 13C-labeled glucose. Metab. Eng. 4: 202-216.
  • C. Yang, Q. Hua and K. Shimizu (2002). Integration of the information from gene expression and metabolic fluxes for the analysis of the regulatory mechanisms in Synechocystis. Appl. Microbiol. Biotechnol. 58:813-822.
  • C. Yang, Q. Hua and K. Shimizu (2002). Quantitative analysis of intracellular metabolic fluxes using GC-MS and two-dimensional NMR spectroscopy. J Biosci. Bioeng. 93:78-87.
  • Q. Hua, C. Yang and K. Shimizu (2001). Design of metabolic regulatory structures for enhanced lysine synthesis flux using (log)linearized kinetic models. Biochem. Eng. J. 9:49-57.
  • C. Yang, Q. Hua and K. Shimizu (2001). Regulation analysis by combining the information obtained from the mRNA expression, protein expression and metabolic fluxes. Genome Informatics, 12:296-297.
  • C. Yang, Q. Hua and K. Shimizu (2000). Energetics and carbon metabolism during growth of microalgal cells under photoautotrophic, mixotrophic and cyclic light-autotrophic/dark-heterotrophic conditions. Biochem. Eng. J. 6:87-102.
  • Q. Hua, C. Yang and K. Shimizu (2000). Metabolic control analysis for lysine synthesis using Corynebacterium glutamicum and experimental verification. J Biosci. Bioeng. 90:184-192.
  • J. Hata, Q. Hua, C. Yang, K. Shimizu and Masahito Taya (2000). Characterization of energy conversion based on metabolic flux analysis in mixotrophic liverwort cells, Marchantia polymorpha. Biochem. Eng. J. 6:65-74.
  • C. Yang, Q. Hua and K. Shimizu (1999). Development of a kinetic model for L-lysine biosynthesis in Corynebacterium glutamicum and its application to metabolic control analysis. J. Biosci. Bioeng. 88:393-403.
  • Q. Hua, C. Yang and K. Shimizu (1999). Metabolic flux analysis for efficient pyruvate fermentation using vitamin-auxotrophic yeast of Torulopsis glabrata. J. Biosci. Bioeng. 87:206-213.
  • Q. Hua, P.-C. Fu, C. Yang and K. Shimizu (1998). Microaerobic lysine fermentations and metabolic flux analysis. Biochem. Eng. J. 2:89-100.