Rickert Lab

People
 

Lutz Tautz
Research Assistant Professor     

tautz@sanfordburnham.org

Novel Delivery Technology for Potential Drugs for Cervical Cancer

Education
M.S. (Chemistry) University of Karlsruhe, Germany, 1997

Ph.D. (Chemistry), University of Karlsruhe, Germany 2002

Publications

Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T (2005) Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem 280:9400- 9408.

Mustelin T, Tautz L, Page R (2005). Structure of the Hematopoietic Tyrosine Phosphatase (HePTP) Catalytic Domain: Structure of a KIM phosphatase with a phosphate bound at the active site. J Mol Biol 354:150-163.

Vang T, Congia M, Macis MD, Musumeci L, Orru V, Zavattari P, Nika K, Tautz L, Tasken K, Cucca F, Mustelin T, Bottini N (2005) Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of- function variant. Nat Genet 37:1317-1319.

Tautz L, Pellecchia M, Mustelin T (2006) Targeting the PTPome in human disease. Expert Opin Ther Targets 10:157-177.

Tautz L, Mustelin T (2007) Strategies for developing protein tyrosine phosphatase inhibitors. Methods 42:250-260.

Krishna SS*, Tautz L*, Xu Q, McMullan D, Miller MD, Abdubek P, Ambing E, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Elsliger MA, Grzechnik SK, Hale J, Hampton E, Han GW, Haugen J, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Koesema E, Morse AT, Mustelin T, Nigoghossian E, Oommachen S, Reyes R, Rife CL, van den Bedem H, Weekes D, White A, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA (2007) Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 angstroms resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases. Proteins 69:415-421. (*equal contributions)

Vang T., Miletic A.V., Arimura, Y., Tautz L., Rickert, R.C., and Mustelin, T. (2008) Protein Tyrosine Phosphatases in Autoimmunity. Annu Rev Immunol 26:29-55.

Arimura, Y., Vang, T., Tautz, L., Williams, S., and Mustelin, T. (2008) TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses. Mol Immunol 45:3074-84.

Xie, Y., Liu, Y., Gong, G., Rinderspacher, A., Deng, S-X., Smith, D.H., Toebben, U., Tzilianos, E., Branden, L., Vidović, D., Chung, C., Schürer, S., Tautz L., Landry, D.W. (2008) Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase. Bioorg Med Chem Lett 18:2840-4.

Henkens, R., Delvenne, P., Arafa, M., Moutschen, A., Zeddou, M., Tautz L., Boniver, J., Mustelin, T., and Rahmouni, S. (2008) Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity proteinphosphatase VHR. BCM Cancer 8:147.

Dawson, M.I., Xia, Z., Jiang, T., Ye, M., Fontana, J.A., Farhana, L., Patel, B., Xue, L.P., Bhuiyan, M., Pellicciari, R., Macchiarulo, A., Nuti, R., Zhang, X.K., Han, Y.H., Tautz L., Hobbs, P.D., Jong, L., Waleh, N., Chao, W.R., Feng, G.S., Pang, Y., Su, Y. (2008) Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Group on Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity. J Med Chem 51:5650-62.

Wu, S., Bottini, M., Rickert, R.C., Mustelin, T., Tautz L. (2009) In Silico Screening for PTPN22 Inhibitors: Active Hits From an Inactive Phosphatase Conformation. ChemMedChem. 4(3):440-4.

Wu, S*., Vossius, S.*, Rahmouni, S.*, Miletic, A.V., Vang, T., Vazquez-Rodriguez, J., Cerignoli, F., Arimura, Y., Williams, S., Hayes, T., Vasile, S., Pellecchia, M., Mustelin, T., and Tautz, L. (2009) Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells. J Med Chem 12:6716-23. (*shared authorship).

Wu, D., Pang, Y., Ke, Y., He, Z., Tautz, L., Mustelin, T., and Feng, G.S. (2009) A Conserved Mechanism for Control of Human and Mouse Embryonic Stem Cell Pluripotency by Shp2. PLos ONE 4:e4914.

Tautz, L. and Rétey, J. (2010) A highly convergent synthesis of myristoyl-carba(dethia)-coenzyme A. Eur. J. Org. Chem. 2010:1728–35.

Critton, D.A., Tautz, L., Page, R. (2010) Visualizing Active-Site Dynamics in Single Crystals of HePTP: Opening of the WPD Loop Involves Coordinated Movement of the E Loop. J Mol Biol. 405(3):619-29

Bobkova, E.V., Liu, W.H., Colayco, S., Rascon, J., Vasile, S., Gasior, C., Critton, D.A., Chan, X., Dahl, R., Su, Y., Sergienko, E., Chung, T.D.Y., Mustelin, T., Page, R., Tautz, L. (2010) Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids. ACS Med Chem Lett Articles ASAP, Publication Date (Web): November 9, 2010, DOI: 10.1021/ml100103p.

Vang, T., Xie, Y., Liu, W.H., Vidovic, D., Liu, Y., Wu, S., Smith, D.H., Rinderspacher, A., Chung, C., Gong, G., Mustelin, T., Landry, D.L., Rickert, R.C., Schuerer, S.C., Deng, S., Tautz, L. (2010) Inhibition of Lymphoid Tyrosine Phosphatase by Benzofuran Salicylic Acids. J Med Chem. 54:562-71.

Bobkova, E.V., Liu, W.H., Colayco, S., Rascon, J., Vasile, S., Gasior, C., Critton, D.A., Chan, X., Dahl, R., Su, Y., Sergienko, E., Chung, T.D.Y., Mustelin, T., Page, R., Tautz, L. (2011) Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids. ACS Med Chem Lett 2:113-118.

Sergienko E, Xu J, Liu WH, Dahl R, Critton DA, Su Y, Brown BT, Chan X, Yang L, Bobkova EV, Vasile S, Yuan H, Rascon J, Colayco S, Sidique S, Cosford ND, Chung TD, Mustelin T, Page R, Lombroso PJ, Tautz L. (2011) Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation. ACS Chem Biol. 7:367-377.

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Francis D, Musumeci L, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L (2012) LYP inhibits T cell activation when dissociated from CSK. Nat Chem Biol 8:437-446.