Suresh Chintalapati
Postdoctoral Associate

suresh@sanfordburnham.org

B cell receptor signaling

The fate of a B cell is determined by signaling through the B cell receptor (BCR). Naïve B cells expressing IgM and IgD as surface receptors respond to antigen and undergo somatic hypermutation and class switch recombination, in a T-dependent manner. Class switched, IgG-BCRs transmit a signal distinct from that of a mature naïve IgM-BCR or IgD-BCR, although all three use the same signal-transducing components, Igα/Igβ. IgG is distinct from IgM/IgD in that it contains a long (25 amino acid) cytoplasmic tail. Though there are reports that suggest that IgG-BCRs transduce more robust signals than IgM- or IgD-BCRs owing to the longer cytoplasmic tail, specific molecular effectors responsible for such hyper-responsiveness have not been revealed. My research interest primarily focuses on understanding these signaling differences mediated by IgG-BCR and IgM/D- BCRs.

Education
1993-1996 B.Sc. in Microbiology, Genetics, & Chemistry, Osmania University, Hyderabad, India

1996-1998 M.Sc. in Biotechnology, University of Hyderabad, Hyderabad, India

1998-2004 Ph.D. in Microbiology, Centre for Cellular and Molecular Biology, Hyderabad, India

Publications

Cato, M.H., I.W. Yau and R.C. Rickert. 2011. Magnetic-based purification

of  "untouched" murine germinal center B cells for ex- vivo manipulation

and biochemical analysis. Nat. Protocols. 9;6(7):953 60.

doi:10.1038/nprot.2011.344.

Cato, M.H., S.K. Chintalapati, I.W. Yau, S.A. Omori and R.C. Rickert. 2011. Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol. Cell. Bio. (1):127-37 .

Browne, C.D., M.M. Hoefer, S.K. Chintalapati, M.H. Cato, Y. Wallez, E.B. Pasquale and R.C. Rickert. 2010. SHEP1 partners with CasL to promote marginal zone B cell maturation. Proc. Natl. Acad. Sci. USA. 107(44):18944-9.

Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, et al. Complement C3d Conjugation to Anthrax Protective Antigen Promotes a Rapid, Sustained, and Protective Antibody Response. PLoS ONE (2007) 2(10): e1044. doi:10.1371/journal.pone.0001044.

Daniel E. Mason, Suresh Chintalapati, Robert C. Rickert and Wayne F Patton. Isolation and Identification of Tyrosine Phosphorylated Peptides from Primary B-cells Using Phos-Trap and Mass Spectrometry. Application Notes, Perkin Elmer(2007) http://las.perkinelmer.com/content/ applicationnotes/app_phostraptyrosinepeptideid.pdf.

Chintalapati, S., Prakash, J.S.S., Gupta, P., Ohtani, S., Suzuki, I., Sakamoto, T., Murata, N. and Shivaji, S. 2006. A novel  Δ9 acyl-lipid desaturase, DesC2, from cyanobacteria acts on fatty acids esterified to the sn-2 position of glycerolipids. Biochem. J. Sep 1;398(2):207-14. 

Shivaji S., Reddy G.S.N., Suresh K., Gupta P., Chintalapati S., Schumann P., Stackebrandt E. and Matsumoto G. 2005. Two novel Psychrobacter species from Antarctica: description of Psychrobacter vallis sp. nov and Psychrobacter aquaticus sp. nov. Int. J. Syst. Evol. Microbiol. Mar;55(Pt 2):757-62.  

Suresh Chintalapati, Kiran Madanahalli, and Sisinthy Shivaji.  2004. Role of membrane lipid fatty acids in cold adaptation. Cell Mol Biol (Noisy-le-grand). Jul;50(5):631-42. 

S. Venkata Mohan, Srinivas Sistla, R. Kumar Guru, K. Krishna Prasad, C. Suresh Kumar, S.V. Ramakrishna, P. N. Sarma. 2003.  Microbial degradation of pyridine using Pseudomonas sp. and isolation of plasmid responsible for degradation. Waste Management.  23 167–171.  

Outside Interests
Traveling and a passion for Indian music!