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Sidne Omori
Staff Scientist
somori@sanfordburnham.org
Regulation of Class Switch Recombination and Plasma Cell Formation by PI3K
During a T-dependent (TD)
immune response, an activated B cell makes a cell fate decision to become a
high-rate immunoglobulin secreting plasma cell, or to enter into a germinal
center reaction and undergo the processes of class switch recombination (CSR)
and somatic hypermutation (SHM). Terminal gene targets required to initiate
these processes have been identified; BLIMP1 for ASC differentiation, BCL6 for
GC formation, and AID for CSR and SHM. However, the signaling pathway(s) that
trigger the expression of these genes remains largely unknown. The major
objective of my current research is determining the role of PI3K in terminal B
cell differentiation down the plasma cell, class switch recombination (CSR), or
germinal center (GC) pathways.
Education
A.B. (Biology), Occidental College, Los Angeles, CA, 1984
Ph.D. (Microbiology/ Immunology), University of California, Los Angeles 1988
Publications
Cato, M.H., S.K. Chintalapati,
I.W. Yau, S.A. Omori and R.C. Rickert. 2011. Cyclin D3 is selectively required
for proliferative expansion of germinal center B cells. Mol. Cell. Bio.
31(1):127-37.
Baracho, G.V., A.V. Miletic, S.A. Omori, M.H. Cato and R.C. Rickert. 2011.
Emergence of the PI3-kinase pathway as a central modulator of normal and
aberrant B cell differentiation. Curr. Opin. Immunol. 23(2):178-83.
Miletic A.V., A.N. Anzelon-Mills,
D.M. Mills, S.A. Omori, I.M. Pedersen, J.V. Ravetch, S. Bolland, H. C. Morse III
and R.C. Rickert. Coordinate suppression of B cell lymphoma by PTEN and SHIP.
2010. J. Exp. Med. 207(11):2407-20.
Cato, M.H., S.K. Chintalapati,
I.W. Yau, S.A. Omori and R.C. Rickert. 2011. Cyclin D3 is selectively required
for proliferative expansion of germinal center B cells. Mol. Cell. Bio. In
press.
Dengler, S.H., G.V.
Baracho, S.A. Omori, S. Bruckner, K.C. Arden, D.H. Castrillon, R.A. Depinho and
R.C. Rickert. 2008. Distinct functions for the transcription factor Foxo1
at various stages of B cell differentiation. Nat. Immunol.
12:1388-98.
Omori, SA, and
Rickert, RC. 2007. Phosphatidylinositol 3-kinase (PI3K)
Signaling and Regulation of the Antibody Response.
Cell
Cycle,
6(4):397-402.
Omori, S.A., M.H. Cato, A. Anzelon-Mills,
K.D. Puri, M. Shapiro-Shelef, K. Calame, and R.C. Rickert. (2006). Regulation
of class switch recombination and plasma cell differentiation by the PI3K/Akt/Foxo
signaling axis. Immunity 25: 545-558.
Qian, Y., J. Qin, G. Cui, M. Naramura, E.C.
Snow, C.F. Ware, R.L. Fairchild, S.A. Omori, R.C. Rickert, B.L. Kotzin and X.
Li. (2004). Act1, a negative regulator in CD40- and BAFF-mediated B cell
survival. Immunity 21: 575-587.
Del Nagro, C.J., D.C. Otero, A.N. Anzelon,
S.A. Omori, R.V. Kolla and R.C. Rickert. (2004). CD19 function in central and
peripheral B cell development. Immunol. Res. 39: 119-132.
Li, Z-W., S.A. Omori, T. Labuda, M. Karin
and R.C. Rickert. (2003). IKKb is required for peripheral B cell proliferation
and survival. J. Immunol. 170: 4630-4637.
Otero, D., S. A. Omori and R. C. Rickert.
(2001). CD19-dependent activation of Akt kinase in B lymphocytes. J Biol
Chem. 276: 1474-1478.
Omori, S.A., Otero, D.C., and Rickert, R.C.
(2000). Regulation of B-cell activation by the co-receptors: The CD19
connection. In: Antibodies. Capra, D. and Zanetti, M., eds. Academic
Press, Burlington, MA.
Malone, C.S., Omori, S.A., and Wall, R.
(1997). Silencer elements controlling the B29 (Ig-β) promoter are neither
promoter- nor cell-type-specific. Proc. Natl. Acad. Sci., USA 94:
12314-12319.
Omori, S.A., Smale, S.T.,
O'Shea-Greenfield, A., and Wall, R. (1997). Differential interaction of
nuclear factors with the leukocyte-specific pp52 promoter in B and T cells.
J. Immunol. 159: 1800-1808.
Thompson, A.A., Wood, Jr., W.J., Gilly,
M.J., Omori, S.A., and Wall, R. (1996). The promoter and 5' flanking
sequences controlling human B29 gene expression. Blood, 87: 666-673.
Thompson, A.A., Omori, S.A., Gilly, M.,
May, W., Gordon, M., Wood, Jr., W.J., Miyoshi, E., Malone, C.S., Gimble, J.,
Denny, C.T., and Wall, R. (1995). Alternatively spliced exons encode the
tissue specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms.
Genomics 32: 352-357.
Damore, M.A., Omori, S.A., and Wall, R.
(1995). Interferon-γ induces the κ intron enhancer via an ISRE. J. Immunol.
156: 2451-2457.
Omori, S.A., and Wall, R. (1993).
Multiple motifs regulate the B-cell specific promoter of the B29 gene. Proc.
Natl. Acad. Sci., USA 90: 11723-11727.
Zhou, L.J., Ord, D.C., Omori, S.A., and
Tedder, T.F. (1992). Structure of the genes encoding the CD19 antigen of human
and mouse B lymphocytes. Immunogenetics 35: 102-111.
Martin, G., Hose, J.E., Omori, S., Chong, C., Hoodbhoy, T., and McKrell, N.
(1991). Localization and roles of coagulogen and transglutaminase in hemolymph
coagulation in decapod crustaceans. Comp. Biochem. Physiol. 100B:
517-522.
Omori, S.A., Martin, G., and Hose, J.E. (1989). Morphology of hemocyte lysis
and clotting in the ridgeback prawn, Sicyonia ingentis. Cell. Tiss. Res.
255: 117-123.
Outside Interests
Cooking, growing orchids, and playing golf. |
