of MALT1, cIAP2-MALT1 and proteolytic targets in the B lineage.
lymphoid tissue (MALT) lymphoma is a form of low-grade marginal zone B cell
lymphomas that arises from a background of chronic inflammatory disease at a
number of mucosal sites. Recurrent chromosomal translocations have been
described in MALT lymphoma, with the most common one being a t(11;18)
translocation that results in a fusion protein containing cellular inhibitor of
apoptosis protein 2 (cIAP2) and the paracaspase MALT1. The cIAP2-MALT1 fusion
protein is capable of activating the NF-κB pathway constitutively. Yet, no
comparative analysis of cIAP2-MALT1 versus its normal counterpart has been
performed. It has been shown that MALT1 possesses protease activity and two of
its substrates that have been described are A20 and BCL-20. However, it remains
unclear whether the function of cIAP2-MALT1 or MALT1 is strictly dependent on
its proteolytic activity. My research will address these knowledge gaps by
utilizing a chimera mouse model to determine the effects of MALT1 and
cIAP2-MALT1 on B cell differentiation, longevity, function, and transformation.
The role of MALT1-mediated substrate cleavage in human B cell lymphoma will also
2009-present University of California, San Diego, Biomedical sciences
2005-2007 National Taiwan University, M.S. in Biochemical Sciences
2001-2005 California Institute of Technology, B.S. in Biology
Chen YT, Ross DS, Chiu R, Zhou XK, Chen YY,
Lee P*, Hoda SA, Simpson AJ, Old LJ, Caballero O, Neville AM. Multiple
cancer/testis antigens are preferentially expressed in hormone-receptor negative
and high-grade breast cancers. PLoS One. 18;6(3):e17876. 2011.
Chen YT, Chadburn A, Lee P*, Hsu M, Ritter
E, Chiu A, Gnjatic S, Pfreundschuh e, Knowles DM, Old LJ. Expression of cancer
testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas.
Proc Natl Acad Sci. 107: 3093-3098, 2010
Chen YT, Hsu M, Lee P*, Shin SJ, Mhawech-Fauceglia P, Odunsi K, Altorki NK, Song
CJ, Jin BQ, Simpson AJ, Old LJ. Cancer/Testis Antigen CT45: Analysis of mRNA and
Protein Expression in Human Cancer. Int J Cancer. 124(12): 2893-2898, 2009
Chang WW, Lee CH, Lee P*, Lin J, Hsu CW, Hung JT, Lin JJ, Yu J, Wong CH, Yu JC,
Shao LE, Yu AL. Expression of Globo H and SSEA3 in breast cancer stem cells and
the involvement of fucosyltransferases 1 & 2 in Globo H synthesis. Proc Natl
Acad Sci. 105: 11667-11672, 2008
Piano, keyboardist in a rock band, cooking/baking, karaoke, photography,
traveling, Hip-Hop dance, anime drawing.