function in B cells
NFkappaB is a
family of transcription factors that play a central role in the inducible
expression of many genes involved in innate and adaptive immunity. The two
dominant signaling pathways that can lead to activation of NFkappaB are termed
the classical and alternative pathways. NIK mediated IKKalpha phosphorylation
activates the alternative NFkappaB pathway, which is characterized by the
cleavage of p100 and generation of the NFkappaB heterodimer p52/RelB. IKKalpha
is not only a crucial part of the alternative NFkappaB pathway, but also
displays NFkappaB independent functions. My work is focused on investigating the
B cell intrinsic functions of IKKalpha in germinal center B cell
differentiation, plasma cell formation and maintenance.
2002-2007 M.S. (Biology),
Department of Genetics, University of Erlangen, Germany
2007-2010 Department of Genetics, University of Erlangen, Germany
Ph.D awarded June 7, 2010 (Summa Cum Laude)
Sitte, S., Jellusova,
J., Weisel, F., Gläsner, J., Pardi, R., and Gessner, A. (2012) JAB1 is essential
for B cell development and germinal center formation and inversely regulates Fas
Ligand and Bcl6 expression. J Immunol. 88(6):2677-86.
Jellusova J and Nitschke L (2011). Regulation of B cell functions by the sialic
acid-binding receptors Siglec-G and CD22. Front. Immun. 2:96.
J. Jellusova and A.V. Miletic. 2011. Signaling by the tumor necrosis factor
receptor superfamily in B-cell biology and disease. Immunol. Rev.
244(1):115-33. doi: 10.1111/j.1600-065X.2011.01067.x.
Jellusova, J., Duber, S., Guckel, E., Binder, C.J., Weiss, S., Voll, R., and
Nitschke, L. Siglec-G regulates B1 cell survival and selection.(2010) J Immunol
Jellusova, J., Wellmann, U., Amann, K., Winkler, T.H., and Nitschke, L. CD22 x
Siglec-G double-deficient mice have massively increased B1 cell numbers and
develop systemic autoimmunity.(2010) J Immunol 184, 3618-3627.
Hoffmann, A., Kerr, S., Jellusova, J., Zhang, J., Weisel, F., Wellmann, U.,
Winkler, T.H., Kneitz, B., Crocker, P.R., and Nitschke, L. (2007). Siglec-G is a
B1 cell-inhibitory receptor that controls expansion and calcium signaling of the
B1 cell population. Nat Immunol 8, 695-704.
Painting, trying to learn Java, setting up campfires whenever and wherever