The general focus of the lab is to better understand the molecular determinants of B lymphocyte differentiation in the normal and disease state.  By necessity, these studies explore the in vivo environments of the primary (bone marrow) and secondary (spleen and lymphnode) lymphoid tissues, but also extend to tertiary sites to address infection, inflammation, autoimmunity and B cell neoplasia.  Conditional gene targeting is widely applied to assess gene function and establish key signaling networks operating at distinct stages of B cell differentiation.  In addition, in vitro cell culture systems, microscopy, flow cytometry and signal transduction approaches are utilized to examine cell-cell interactions and the molecular basis of B cell responses to antigen, cytokines, growth factors and metabolites.

I am among those who think that science has great beauty. A scientist in his laboratory is not only a technician: he is also a child placed before natural phenomena which impress him like a fairy tale.
  - Marie Curie