The general focus of the
lab is to better understand the molecular determinants of B
lymphocyte differentiation in the normal and disease state. By
necessity, these studies explore the in vivo environments
of the primary (bone marrow) and secondary (spleen and lymphnode)
lymphoid tissues, but also extend to tertiary sites to address
infection, inflammation, autoimmunity and B cell neoplasia.
Conditional gene targeting is widely applied to assess gene
function and establish key signaling networks operating at
distinct stages of B cell differentiation. In addition, in
vitro cell culture systems, microscopy, flow cytometry and
signal transduction approaches are utilized to examine cell-cell
interactions and the molecular basis of B cell responses to
antigen, cytokines, growth factors and metabolites.
I am among those who think that science
has great beauty. A scientist in his laboratory is not only a
technician: he is also a child placed before natural phenomena
which impress him like a fairy tale.
- Marie Curie