Wanda Reynolds

Wanda Reynolds, Ph.D.[La Jolla]

  • Associate Investigator
  • Research

    Dr. Reynolds lab has found that a genetic mutation in the human MPO gene causes it to be aberrantly expressed, contributing to disease.

  • Biography

    Dr. Reynolds earned her Ph.D. at the University of California at Davis in 1980.

Publications
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Wanda Reynolds's Research Focus

Our laboratory studies the mechanisms by which oxidative damage contributes to major diseases of aging, including atherosclerosis, neurodegenerative disease, and cancer. Our main focus is myeloperoxidase (MPO), an oxidant generating enzyme that is aberrantly expressed in these disease states in humans. Our studies revealed a primate specific mutation in the human MPO promoter that leads to atypical expression, such as in astrocytes in Alzheimer’s disease, and macrophages in atherosclerosis, leading to oxidative damage and cell death. On the other hand, aberrant expression of MPO in breast cancer cells is protective, reducing incidence of recurrence following chemotherapy. We are investigating the molecular signals that lead to this atypical induction of MPO and analyzing the oxidative impact on cellular function and survival. We are also screening for small molecule antagonists of MPO that could serve as therapeutic agents.
 

About Wanda Reynolds

Experience

Wanda Reynolds earned her Ph.D. at the University of California at Davis in 1980. After postdoctoral training at the Scripps Research Institute, she was appointed Assistant Member in 1984, and joined the La Jolla Cancer Research Institute in 1988. She was appointed Associate Professor at the Sidney Kimmel Cancer Center in 1994, and joined the Sanford-Burnham Medical Research Institute in 2010.

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