Timothy Osborne

Timothy Osborne, Ph.D.[Lake Nona in Orlando]

Over the past generation, the costs associated with Diabetes and Obesity to American economy has risen to over $100 billion annually through effects on health care and worker productivity. Research advances that reverse this trend will have a major overall positive effect on the long-term wellness of our Nation as a whole.

  • Research

    Dr. Osborne’s research examines how the body senses differences in the molecular composition of the diet.

  • Biography

    Dr. Osborne received his Ph.D. in Microbiology/Molecular Biology from the University of California, Los Angeles.

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Timothy Osborne's Research Focus

Cardiovascular Diseases, Atherosclerosis, Metabolic Syndrome, Obesity, Type 2 Diabetes, Aging-Related Diseases, Cancer, Heart Disease, Infectious Diseases, Pathogen Invasion, Inflammatory Bowel Disease, Inherited Disorders, Metabolic Diseases, Diabetes - General, Monogenic Diabetes, Type 1 Diabetes

Timothy OsborneWatch Dr. Osborne describe his research

The Osborne laboratory's study into the regulation of cholesterol and fatty-acid metabolism and their interconnectedness has been expanded to determine how lipid metabolism is integrated into more-global aspects of physiology and cell biology. A major focus of their work has been on the sterol-regulatory-element-binding proteins (SREBPs) and over the last 15 years the lab has made and validated several molecular reagents and assay systems for studying SREBPs using in vitro, cell-culture-based and whole-animal model systems. More-recent studies combine animal knockout and genome-wide approaches that indicate SREBPs are at the intersection of nutrient sensing and many other cell-environment interactions including responses to organic and biological threats.

Timothy Osborne's Research Report

Timothy Osborne
The focus of our research is on how fundamental processes of gene regulation are used in the control and management of metabolic homeostasis. Our primary studies are in mammalian lipid metabolism and the two main lipids in mammalian cells are fatty acids and sterols. In one major area, we study how dietary and metabolic fluctuations alter flux of acetyl CoA into either cholesterol or fatty acids. A major decision point for this is at the gene expression level where changes in mRNA levels result in changes in the concentration of key enzymes in the two pathways to alter acetyl CoA flux accordingly. We are using molecular genetic and biochemical techniques to evaluate how the sterol regulatory element binding proteins (SREBPs) sense the need to shift the flux in response to changing metabolic conditions.

About Timothy Osborne

Experience

Timothy Osborne, Ph.D., received his doctorate in Microbiology/Molecular Biology from the University of California, Los Angeles (UCLA), and conducted postdoctoral research in the lab of Nobel Prize winners, Brown and Goldstein at the University of Texas at Southwestern Medical School. Dr. Osborne was most recently chair of the Department of Molecular Biology and Biochemistry at UC Irvine. He received UCI’s Chancellor’s Award for Excellence in Mentoring Undergraduate Research, was elected to Who’s Who in American University Professors, was recognized as an Established Investigator of the American Heart Association and is a recipient of a Lucille P. Markey Scholar Award in Biomedical Science.

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Education

Ph.D., University of California Los Angeles
A.B., University of California Santa Barbara

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