Dr. Lee focuses on understanding the role of genetic factors and environmental cues in endothelial cell biology and vascular morphogenesis.
Dr. Lee earned her Ph.D. in Molecular Biology and Biochemistry from University of Southern California.
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Autocrine VEGF signaling is required for vascular homeostasis.
Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, Desai S, Ferrara N, Nagy A, Roos KP, Iruela-Arispe ML
Cell. 2007 Aug 24;130(4):691-703
Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.
Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON
Mol Cell Biol. 2007 Feb;27(4):1334-47
In vivo expression of a conditional TGF-beta1 transgene: no evidence for TGF-beta1 transgene expression in SM22alpha-tTA transgenic mice.
Lee S, Agah R, Xiao M, Frutkin AD, Kremen M, Shi H, Dichek DA
J Mol Cell Cardiol. 2006 Jan;40(1):148-56
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.
Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML
J Cell Biol. 2005 May 23;169(4):681-91
Receptor-mediated Moloney murine leukemia virus entry can occur independently of the clathrin-coated-pit-mediated endocytic pathway.
Lee S, Zhao Y, Anderson WF
J Virol. 1999 Jul;73(7):5994-6005
Identification of the block in targeted retroviral-mediated gene transfer.
Zhao Y, Zhu L, Lee S, Li L, Chang E, Soong NW, Douer D, Anderson WF
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4005-10
Sunyoung Lee's Research Focus
By using transgenic/knock-out mice as model systems, we aim to understand the role of genetic factors and environmental cues in endothelial cell biology, vascular morphogenesis and their connection with human diseases. Particularly, we focus on the biology of vascular endothelial growth factor (VEGF), VEGF receptors and their interactions with extracellular matrix (ECM) in both physiological and pathological vascular morphogenesis and disease progression. VEGF signaling is essential for specification, morphogenesis, differentiation and homeostasis of vessels both in the embryo and in the adult. Furthermore, this signaling pathway is an integral component of pathological angiogenesis including retinopathies, arthritis, and tumor expansion. Consequently, VEGF has remained one of the most pivotal growth factors for therapeutic exploitation. We are currently dissecting paracrine vs. autocrine VEGF-VEGF receptor signaling in endothelial cells, investigating the intriguing interplay between VEGF and matrix metalloproteinases (MMPs) and, studying the role of autocrine VEGF signaling in organogenesis and hematopoiesis during development.
About Sunyoung Lee
Sunyoung Lee earned her Ph.D. in Molecular Biology and Biochemistry from University of Southern California. Sunyoung was a postdoctoral fellow from 2001-2007 at the University of California, Los Angeles in the laboratory of Dr. Luisa Iruela-Arispe. From 2007-2008, Sunyoung was an assistant researcher at UCLA. Dr. Lee was recruited to Sanford-Burnham Medical Research Institute in 2008.
Ph.D., Yonsei University, Seoul, Molecular Biology & Biochemistry, 2000
B.S., Yonsei University, Seoul, Biochemistry, 1989