Sumit Chanda

  • Research

    Elucidating the repertoire of host proteins required for host-pathogen interaction, as well as cellular control of immune responses.

  • Biography

    Dr. Chanda earned his Ph.D. from Stanford University in 2001.

Publications

 

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Sumit Chanda's Research Focus

Infectious Diseases, HIV/AIDS, Pandemic Influenza, Inflammatory/Autoimmune Disease, Arthritis, Crohn’s Disease (Colitis), Psoriasis, Scleroderma, Systemic Lupus Erythematosus, Cancer

Viruses are obligate pathogens, and therefore their survival is dependent upon their ability to exploit host cellular machinery. Concurrently, viruses must also successfully evade immune surveillance mechanisms, including first-line (innate) defense systems. The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only provide insight into viral pathogenesis, but key regulators of inflammation and innate immunity in cancer.
 

Sumit Chanda's Research Report

Sumit Chanda
We are studying cellular proteins required for both influenza A and retrovirus/HIV infection. Also, we are investigating novel molecules that regulate or respond to Pattern Recognition Receptor (PRR) signaling. Taken together, we aim to elucidate the repertoire of host proteins required for viral infection, and understand the molecular strategies adapted by these viruses as countermeasures to innate immune responses.

To understand these events on a global level, our lab uses a series of systems-level approaches, including genome-wide RNAi, proteomics and protein-protein interaction (PPI) analysis, and high content imaging. These, and other, tools are helping us to build a comprehensive cellular 'roadmap' exploited by these viruses to enable their propagation within a cell. These studies are expected to provide unprecedented insight into the molecular circuitry commandeered by these pathogens to establish infection, and will offer new opportunities for the development of 'next generation' host factor and immune-mediated antivirals.

About Sumit Chanda

Experience

Sumit Chanda earned his Ph.D. from Stanford University in 2001, and received his post-doctoral training at the Genomics Institute of the Novartis Research Foundation (GNF). He subsequently transitioned to a Group Leader position, and established his research group in the Division of Cellular Genomics at GNF. In 2007, he joined the Infectious and Inflammatory Disease Center at Sanford-Burnham Medical Research Institute as an Associate Professor. Dr. Chanda also holds an Adjunct Professor appointment at the Salk Institute for Biological Studies, as well as a Visiting Scientist position at the Genomics Institute of the Novartis Research Foundation.

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Other Appointments

Adjunct Professor, Salk Institute for Biological Sciences
Visiting Scientist, The Genomics Institute of the Novartis Research Foundation
Visiting Scientist, The Scripps Research Institute

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